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Subsequent Positron Emission Tomography (PET)-CT staging revealed right axillary lymphadenopathy and coincidentally diagnosed recurrent non-small cell lung cancer (NSCLC). The PCDLBCL-LT was treated with localised radiotherapy after the patient declined chemotherapy. This case report highlights an unusual presentation of PCDLBCL-LT on the upper limb. It further emphasises the challenges posed in diagnosing and treating solitary skin lesions among older patients with a prior oncological history while highlighting the importance of an individualised multidisciplinary approach for safe and efficacious treatment in the context of advanced age and multiple comorbidities.<\/jats:p>","DOI":"10.1136\/bcr-2024-264401","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T02:30:16Z","timestamp":1748658616000},"page":"e264401","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rare aggressive presentation of primary cutaneous diffuse large B-Cell lymphoma, leg type, in the upper arm with concurrent non-small cell lung cancer"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-8398","authenticated-orcid":false,"given":"Zinab","family":"Alatawi","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk 47512, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Passby","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazia","family":"Kaushal","sequence":"additional","affiliation":[{"name":"University Hospitals Birmingham NHS Foundation Trust, Birmingham, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"2025082712002972000_18.5.e264401.1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.5114\/ada.2021.108444","article-title":"Primary cutaneous diffuse large B-cell lymphoma after total knee arthroplasty: a case study and a systematic review of its cutaneous manifestations and treatment options","volume":"39","author":"Chen","year":"2022","journal-title":"Postepy Dermatol Alergol"},{"key":"2025082712002972000_18.5.e264401.2","first-page":"174","article-title":"Primary cutaneous diffuse large B-cell lymphoma, leg type, with multiple local relapses: case presentation and brief review of literature","volume":"17","author":"Patsatsi","year":"2013","journal-title":"Hippokratia"},{"key":"2025082712002972000_18.5.e264401.3","unstructured":"Swerdlow SH , Campo E , Harris NL , et al . 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