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The tumour tested positive for oestrogen and progesterone receptors but negative for HER2; genetic testing revealed the patient harboured germline mutations for BRCA1 and BRCA2. Oncology initiated anastrozole and palbociclib treatment, resulting in objective improvement in his breast cancer and his CE. This case highlights a unique presentation of male breast cancer with CE in the context of BRCA mutations and underscores the importance of genetic evaluation and tailored treatment in men with familial breast cancer syndromes.<\/jats:p>","DOI":"10.1136\/bcr-2024-264429","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T16:25:23Z","timestamp":1744734323000},"page":"e264429","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Carcinoma erysipeloides secondary to male breast cancer in a patient with BRCA1 and BRCA2 mutations: a clinical presentation and management"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3956-5573","authenticated-orcid":false,"given":"Ayushya","family":"Ajmani","sequence":"first","affiliation":[{"name":"Dartmouth College Geisel School of Medicine, Hanover, New Hampshire, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W","family":"Witheiler","sequence":"additional","affiliation":[{"name":"Methodist Health System, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Kivelevitch","sequence":"additional","affiliation":[{"name":"Dermatology, Baylor Scott & White Health, Dallas, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"2025082703421052000_18.4.e264429.1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21834"},{"key":"2025082703421052000_18.4.e264429.2","unstructured":"BRCA Gene Changes: Cancer Risk and Genetic Testing Fact Sheet - NCI, 2024. 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