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This phenomenon is caused by excessive in vitro glycolysis, which can be mitigated by rapid sample processing or the use of tubes containing glycolysis inhibitors. This case report adds to the existing body of evidence on artefactual hypoglycaemia with the aim of raising awareness of this entity among healthcare professionals. In asymptomatic individuals with low glucose measurements, the possibility of spurious results should be considered prior to initiating further diagnostic work-up.<\/jats:p>","DOI":"10.1136\/bcr-2024-264459","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T02:17:21Z","timestamp":1742955441000},"page":"e264459","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Leucocytosis-induced artefactual hypoglycaemia in the setting of chronic neutrophilic leukaemia"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5455-4193","authenticated-orcid":false,"given":"Katherine","family":"Drummond","sequence":"first","affiliation":[{"name":"Department of Medicine, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-1171","authenticated-orcid":false,"given":"Nisha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, McGill University, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7892-5165","authenticated-orcid":false,"given":"Elizabeth","family":"Mac Namara","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Jewish General Hospital, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-5914","authenticated-orcid":false,"given":"Stavroula","family":"Christopoulos","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Jewish General Hospital, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"2025082713091390000_18.3.e264459.1","unstructured":"Rayas MS , Hypoglycemia SMN-D . 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