{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:10:20Z","timestamp":1756379420993,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,3,18]]},"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:p>A postpartum woman in her 40s, with a history of peripartum cardiomyopathy, developed neutropenic sepsis after a caesarean section and hysterectomy for placenta previa. She presented with high fever, respiratory distress, and splenomegaly, along with severe neutropenia (absolute neutrophil count &lt;100\u2009cells\/mm\u00b3). Blood cultures showed coagulase-negative staphylococci, and viral tests were positive for cytomegalovirus (CMV). A suspected complication of haemophagocytic lymphohistiocytosis (HLH) following CMV infection was considered. Broad-spectrum antibiotics, corticosteroids, granulocyte-macrophage colony-stimulating factor and intravenous immunoglobulin were administered. There was marked improvement as the patient became afebrile, with the return of neutrophils and stabilisation of her vital parameters. Follow-up at 3 and 6 months post-admission showed that the patient remained clinically improved with no subsequent complications. This case highlights the challenging management of neutropenic sepsis complicated by HLH provoked by CMV in a postpartum woman.<\/jats:p>","DOI":"10.1136\/bcr-2024-264486","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:51:48Z","timestamp":1743144708000},"page":"e264486","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Neutropenic sepsis and CMV-induced haemophagocytic lymphohistiocytosis in the postpartum period"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2687-3529","authenticated-orcid":false,"given":"Akash","family":"Paruthi","sequence":"first","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra Kumar","family":"Kasana","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sawai Man singh Medical College and Hospital, Jaipur, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"2025082803351962000_18.3.e264486.1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"2025082803351962000_18.3.e264486.2","doi-asserted-by":"crossref","unstructured":"Jordan MB , Allen CE , Greenberg J , et al . 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