{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:11:14Z","timestamp":1769580674217,"version":"3.49.0"},"reference-count":17,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,5,9]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>A patient presented with fatigue, weight loss, haemoptysis, bullous rash and spiculated pulmonary nodules. Skin biopsy was consistent with Sweet\u2019s syndrome (SS). Pertinent labs included a positive c- anti-neutrophil cytoplasmic antibody (ANCA) and positive proteinase 3 (PR3) antibody. Additional work-up included a lung biopsy which revealed multinucleated giant cells and repeat skin biopsy with small and medium vasculitis, leading to a diagnosis of granulomatosis with polyangiitis (GPA). SS is a neutrophilic dermatosis that often presents with malignancy, drugs or infection. SS has rarely been described in association with ANCA-vasculitis, with few reports of SS as a presenting symptom. Patients presenting with SS and additional features concerning for ANCA-vasculitis may benefit from further workup for vasculitis given the high morbidity and mortality associated with the disease.<\/jats:p>","DOI":"10.1136\/bcr-2024-264722","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T23:25:23Z","timestamp":1748301923000},"page":"e264722","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Sweet\u2019s syndrome as a presenting symptom of granulomatosis with polyangiitis"],"prefix":"10.1136","volume":"18","author":[{"given":"Teresa","family":"Xiao","sequence":"first","affiliation":[{"name":"Medicine, The University of Chicago, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailia","family":"Ali","sequence":"additional","affiliation":[{"name":"Medicine, The University of Chicago, Chicago, Illinois, 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