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The vision in the affected eye was normal and there were no associated ocular or systemic complaints. The left eye had a solitary amelanotic nodule with intrinsic vessels on the temporal iris. An excision biopsy with histopathology revealed features of metastatic adenocarcinoma. Immunohistochemistry workup pointed towards a primary in the lungs. A high-resolution chest CT scan showed an upper lobe mass in the right lung. A whole-body positron emission tomography\u2013CT (PET\u2013CT) scan showed this lesion to be metabolically active. Additionally, it showed active mediastinal and supraclavicular lymph nodes, and active lesions in the brain parenchyma. The patient received chemo- and radiation therapy with palliative intent at a general oncology facility.<\/jats:p>","DOI":"10.1136\/bcr-2025-264917","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T01:35:16Z","timestamp":1744335316000},"page":"e264917","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Iris metastasis: clues to the primary through immunohistochemistry"],"prefix":"10.1136","volume":"18","author":[{"given":"Mohammed","family":"Almanassra","sequence":"first","affiliation":[{"name":"Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Sucharita","sequence":"additional","affiliation":[{"name":"Kanupriya Dalmia Ophthalmic Pathology Laboratory, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanta Kumar","family":"Padhy","sequence":"additional","affiliation":[{"name":"Vitreoretinal Service, Anant Bajaj Retina Institute, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devjyoti","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Ophthalmic Plastic Surgery, Orbit and Ocular Oncology, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"2025082704103590000_18.4.e264917.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30148-1"},{"key":"2025082704103590000_18.4.e264917.2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/ICO.0000000000000285","article-title":"Iris metastasis from systemic cancer in 104 patients: the 2014 Jerry A. 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