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This case highlights the shared clinical features of DNS and influenza-associated encephalopathy, the latter being the eventual diagnosis for our patient. We review the DNS literature focusing on presentation, adequacy of investigation, treatment and prognosis. Finally, we provide an initial workup for patients with suspected DNS, including nasopharyngeal influenza PCR.<\/jats:p>","DOI":"10.1136\/bcr-2025-264930","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T02:35:29Z","timestamp":1742956529000},"page":"e264930","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Influenza-associated encephalopathy mimicking dermatoneuro syndrome"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3190-2627","authenticated-orcid":false,"given":"Matthew","family":"Rode","sequence":"first","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-2648","authenticated-orcid":false,"given":"Michael J","family":"Rigby","sequence":"additional","affiliation":[{"name":"Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-4638","authenticated-orcid":false,"given":"Elke","family":"Schipani","sequence":"additional","affiliation":[{"name":"Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7479-6732","authenticated-orcid":false,"given":"Jennifer","family":"Fugate","sequence":"additional","affiliation":[{"name":"Neurology, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"2025082801391847000_18.3.e264930.1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/jdv.19937","article-title":"Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxoedema and 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