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Multilayered haemorrhages involving the macula were confirmed through funduscopy and swept-source optical coherence tomography. The patient underwent pars plana vitrectomy with subretinal recombinant tissue plasminogen activator injection, fluid-gas exchange with sulphur hexafluoride, and intravitreal ranibizumab, followed by prone positioning postoperatively. At 1\u2009week, significant resolution of subretinal haemorrhage and improvement in exudative retinal detachment were observed. By 3\u2009months, best-corrected visual acuity improved to 20\/60, with consolidation of the haemorrhage and shrinkage of the pigment epithelial detachment.<\/jats:p>","DOI":"10.1136\/bcr-2025-265059","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T03:46:13Z","timestamp":1747971973000},"page":"e265059","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Subretinal tissue plasminogen activator in polypoidal choroidal vasculopathy-related submacular haemorrhage and exudative retinal detachment"],"prefix":"10.1136","volume":"18","author":[{"given":"Mannat","family":"Giran","sequence":"first","affiliation":[{"name":"Anant Bajaj Retina Institute, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Almoparzy","sequence":"additional","affiliation":[{"name":"Anant Bajaj Retina Institute, LV 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