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Investigations revealed pulmonary involvement and mediastinal lymphadenopathy, making the tumour inoperable according to National Comprehensive Cancer Network guidelines due to the involvement of essential structures. Neoadjuvant chemotherapy was recommended for this patient. This case underscores the aggressive nature of advanced maxillofacial SCC and emphasises the need for early detection, timely evidence-based treatment and a multidisciplinary approach to enhance patient outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2025-265111","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:10:22Z","timestamp":1753161022000},"page":"e265111","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed diagnosis of advanced maxillofacial squamous cell carcinoma in a rural patient"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9924-4560","authenticated-orcid":false,"given":"Jayesh Dhananjay","family":"Phalak","sequence":"first","affiliation":[{"name":"Department of Oral and maxillofacial Surgery, Shri Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin Dharampal","family":"Bhola","sequence":"additional","affiliation":[{"name":"Department of Oral and maxillofacial Surgery, Shri Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepankar","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Oral and maxillofacial Surgery, Shri Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjana Narendra","family":"Wadewale","sequence":"additional","affiliation":[{"name":"Department of Oral and maxillofacial Surgery, Shri Sharad Pawar Dental College and Hospital, Wardha, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"2025082703250973000_18.7.e265111.1","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1186\/1752-1947-5-291","article-title":"Delayed diagnosis of oral squamous cell carcinoma: a case series","volume":"5","author":"Akbulut","year":"2011","journal-title":"J Med Case Rep"},{"key":"2025082703250973000_18.7.e265111.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"2025082703250973000_18.7.e265111.3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2334\/josnusd.52.267","article-title":"Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection","volume":"52","author":"Marocchio","year":"2010","journal-title":"J Oral Sci"},{"key":"2025082703250973000_18.7.e265111.4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"2025082703250973000_18.7.e265111.5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0016"},{"key":"2025082703250973000_18.7.e265111.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.06.008"},{"key":"2025082703250973000_18.7.e265111.7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.anl.2018.08.011","article-title":"Surgical margins in head and neck cancer: Intra- and postoperative considerations","volume":"46","author":"Thomas Robbins","year":"2019","journal-title":"Auris Nasus Larynx"},{"key":"2025082703250973000_18.7.e265111.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.06.008"},{"key":"2025082703250973000_18.7.e265111.9","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90139-M"},{"key":"2025082703250973000_18.7.e265111.10","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2012.0829"},{"key":"2025082703250973000_18.7.e265111.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.07.015"},{"key":"2025082703250973000_18.7.e265111.12","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1017\/S002221511600058X","article-title":"Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines","volume":"130","author":"Paleri","year":"2016","journal-title":"J Laryngol Otol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:25:21Z","timestamp":1756290321000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,21]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bcr-2025-265111"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265111","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}