{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:40:14Z","timestamp":1756370414650,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,5]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>A woman in early 70s with retinitis pigmentosa (RP) had sudden decrease in vision in her right eye. She previously had cataract surgery in left eye. Her best corrected visual acuity (BCVA) was 20\/80 in the right eye and 20\/200 in the left eye. Examination showed corneal decompensation, advanced pigmentary retinopathy and macular oedema in both eyes.<\/jats:p>\n               <jats:p>Optical coherence tomography (OCT) confirmed bilateral cystoid macular oedema, initially thought to be from pigmentary retinopathy. However, fundus angiography found a vasoproliferative tumour (VPT), measuring 3.187 mm \u00d7 3.477\u2009mm, in the temporal periphery of the right eye, identified as VPT. Multiple Intravitreal ranibizumab injections resolved the macular oedema over few years. During VPT treatment, corneal decompensation worsened in right eye, causing severe corneal oedema and Descemet\u2019s folds, reducing vision to counting fingers.<\/jats:p>\n               <jats:p>She underwent iris claw lens implantation and penetrating keratoplasty (PKP) in the right eye. After surgery, a VPT was clearly visible in the peripheral fundus.<\/jats:p>","DOI":"10.1136\/bcr-2025-265153","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T04:10:32Z","timestamp":1750133432000},"page":"e265153","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual presentation of retinitis pigmentosa with vasoproliferative tumour"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5609-0840","authenticated-orcid":false,"given":"Siraj","family":"Ahmad","sequence":"first","affiliation":[{"name":"Medical College, The Aga Khan University, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6605-2239","authenticated-orcid":false,"given":"Malik Muhammad Hamza","family":"Khan","sequence":"additional","affiliation":[{"name":"Medical College, The Aga Khan University, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehrish Nizar Ali","family":"Momin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Aga Khan University, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroon","family":"Tayyab","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Aga Khan University, Karachi, Sindh, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"2025082801115746000_18.6.e265153.1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)69740-7"},{"key":"2025082801115746000_18.6.e265153.2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4103\/tjo.tjo_21_22","article-title":"Retinal vasoproliferative tumor regression after intravitreal aflibercept","volume":"13","author":"Chu","year":"2023","journal-title":"Taiwan J Ophthalmol"},{"key":"2025082801115746000_18.6.e265153.3","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/eye.2008.351","article-title":"Is vasoproliferative tumour (reactive retinal glioangiosis) part of the spectrum of proliferative vitreoretinopathy?","volume":"23","author":"Hiscott","year":"2009","journal-title":"Eye (Lond)"},{"key":"2025082801115746000_18.6.e265153.4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100050083035"},{"key":"2025082801115746000_18.6.e265153.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69740-7"},{"key":"2025082801115746000_18.6.e265153.6","first-page":"223","article-title":"Population genetic studies of retinitis pigmentosa","volume":"32","author":"Boughman","year":"1980","journal-title":"Am J Hum Genet"},{"key":"2025082801115746000_18.6.e265153.7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1395-3907.2002.00001.x","article-title":"Epidemiology of retinitis pigmentosa in Denmark","volume":"233","author":"Haim","year":"2002","journal-title":"Acta Ophthalmol Scand Suppl"},{"key":"2025082801115746000_18.6.e265153.8","first-page":"268","article-title":"Retinitis Pigmentosa Associated with Vasoproliferative Tumors and Coats-like Fundus","volume":"8","author":"Ghassemi","year":"2013","journal-title":"J Ophthalmic Vis Res"},{"key":"2025082801115746000_18.6.e265153.9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ajo.2012.09.002","article-title":"Reactive Retinal Astrocytic Tumors (So-called Vasoproliferative Tumors): Histopathologic, Immunohistochemical, and Genetic Studies of Four Cases","volume":"155","author":"Poole Perry","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"2025082801115746000_18.6.e265153.10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.amsu.2020.08.039","article-title":"Retinal vasoproliferative tumor in intermediate uveitis: A case report","volume":"59","author":"Mahjoub","year":"2020","journal-title":"Ann Med Surg (Lond)"},{"key":"2025082801115746000_18.6.e265153.11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/j.1755-3768.2008.01447.x","article-title":"Photodynamic therapy with verteporfin for vasoproliferative tumour of the retina","volume":"88","author":"Chan","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"2025082801115746000_18.6.e265153.12","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-240878","article-title":"Retinal vasoproliferative tumour secondary to retinitis pigmentosa sine pigmento","volume":"14","author":"Bromeo","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025082801115746000_18.6.e265153.13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/08164622.2021.1878853","article-title":"Photodynamic therapy for vasoproliferative tumour associated with retinitis pigmentosa and Usher syndrome type 2","volume":"105","author":"Grassi","year":"2022","journal-title":"Clin Exp Optom"},{"key":"2025082801115746000_18.6.e265153.14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1442-9071.2008.01902.x","article-title":"Retinal vasoproliferative tumour as the initial manifestation of retinitis pigmentosa","volume":"36","author":"Li","year":"2008","journal-title":"Clin Exp Ophthalmol"},{"key":"2025082801115746000_18.6.e265153.15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1442-9071.2007.01440.x","article-title":"Photodynamic treatment of a secondary vasoproliferative tumour associated with sector retinitis pigmentosa and Usher syndrome type I","volume":"35","author":"Osman","year":"2007","journal-title":"Clinical Exper Ophthalmology"},{"key":"2025082801115746000_18.6.e265153.16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.4321\/S0365-66912006000600008","article-title":"Juxtapapillary capillary hemangioma and central serous retinopathy: description of a case with spontaneous resolution","volume":"81","author":"Pareja","year":"2006","journal-title":"Arch Soc Esp Oftalmol"},{"key":"2025082801115746000_18.6.e265153.17","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00006982-199010000-00009","article-title":"Retinal hemangioma-like lesions in eyes with retinitis pigmentosa","volume":"10","author":"Medlock","year":"1990","journal-title":"Retina"},{"key":"2025082801115746000_18.6.e265153.18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/npmj.npmj_265_22","article-title":"Bilateral astrocytic hamartoma with vasoproliferative tumour in retinitis pigmentosa","volume":"30","author":"Babalola","year":"2023","journal-title":"Niger Postgrad Med J"},{"key":"2025082801115746000_18.6.e265153.19","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1097\/IAE.0b013e3182923490","article-title":"Expression of vascular endothelial growth factor and intravitreal anti-VEGF therapy with bevacizumab in vasoproliferative retinal tumors","volume":"33","author":"Saito","year":"2013","journal-title":"Retina"},{"key":"2025082801115746000_18.6.e265153.20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.tjo.2016.04.003","article-title":"Clinical characters and treatments of retinal vasoproliferative tumors","volume":"6","author":"Huang","year":"2016","journal-title":"Taiwan J Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:12:04Z","timestamp":1756368724000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,16]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/bcr-2025-265153"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265153","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}