{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:51Z","timestamp":1756339551631,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,8,6]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Cervical teratoblastoma in paediatric patients is an extremely rare and aggressive malignancy, with limited documentation in the medical literature. Teratoblastoma is a malignant variant of germ cell tumours, distinguished by its invasive growth pattern and poor cellular differentiation.<\/jats:p>\n               <jats:p>A female child in early adolescence presented to our oncology hospital with complaints of persistent lower abdominal discomfort and abnormal uterine bleeding. These symptoms had been progressively worsening over time. On physical examination and imaging, pelvic ultrasonography and MRI revealed a complex cystic mass with hypoechoic features, located in the region between the cervix and the hymenal ring. Histopathological evaluation of a biopsy specimen confirmed the diagnosis of malignant cervical teratoblastoma. A multidisciplinary tumour board recommended surgical intervention. The patient underwent transvaginal excision of the cervical mass, with care taken to preserve reproductive anatomy.<\/jats:p>\n               <jats:p>Postoperatively, adjuvant chemotherapy was initiated with the bleomycin, procarbazine (Natulan) and cisplatin regimen to reduce the risk of recurrence and metastasis. This case highlights the importance of early recognition, accurate diagnosis and a coordinated treatment approach in managing rare paediatric cervical malignancies.<\/jats:p>","DOI":"10.1136\/bcr-2025-265218","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:15:22Z","timestamp":1756314922000},"page":"e265218","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cervical teratoblastoma in a paediatric patient: clinical presentation and management"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9052-6754","authenticated-orcid":false,"given":"Mehriniso","family":"Oripova","sequence":"first","affiliation":[{"name":"Oncology, Samarkand State Medical University, Samarkand, Samarkand Province, Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1019-3836","authenticated-orcid":false,"given":"Mushtariy Murotxonovna","family":"Abduvaliyeva","sequence":"additional","affiliation":[{"name":"Oncology, Samarkand State Medical University, Samarkand, Samarkand Province, Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"2025082710151765000_18.8.e265218.1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-3-642-65857-0_2","article-title":"Experimental teratoma","volume":"59","author":"Damjanov","year":"1974","journal-title":"Curr Top Pathol"},{"key":"2025082710151765000_18.8.e265218.2","first-page":"59","article-title":"Ovarian teratoblastoma","volume":"20","author":"SAGI","year":"1957","journal-title":"Magy Noorv Lapja"},{"key":"2025082710151765000_18.8.e265218.3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/ANC.0b013e3181dd6d25","article-title":"Perinatal Germ Cell Tumors","volume":"10","author":"Fichera","year":"2010","journal-title":"Adv Neonatal Care"},{"key":"2025082710151765000_18.8.e265218.4","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1994.01880280072014"},{"key":"2025082710151765000_18.8.e265218.5","first-page":"97","article-title":"The clinical case of diagnosis and treatment of the ovarian teratoblastoma in a child","volume":"1","author":"Kulyk","year":"2024","journal-title":"PS (Wash DC)"},{"key":"2025082710151765000_18.8.e265218.6","first-page":"76","article-title":"Ovarian teratoblastoma in a girl","volume":"21","author":"Vorob\u2019ev","year":"1975","journal-title":"Vopr Onkol"},{"key":"2025082710151765000_18.8.e265218.7","unstructured":"Wein AJ , Kavoussi LR , Novick AC , eds. Testicular germ cell tumors. In: Campbell-Walsh urology. 10th edn. Philadelphia: Elsevier, 2011: 865\u2013908."},{"key":"2025082710151765000_18.8.e265218.8","unstructured":"Ronin VS , Kolesnik OV , Ivanova LN , et al . Teratoblastoma of the lung in a child. Lab Delo 1990;76\u20137."},{"key":"2025082710151765000_18.8.e265218.9","first-page":"73","article-title":"Teratoblastoma of the brain","volume":"34","author":"Sedykh","year":"1972","journal-title":"Arkh Patol"},{"key":"2025082710151765000_18.8.e265218.10","unstructured":"Vasiutkov V la , Chasovskikh VM , Levashov GV . Rezektsiia pravo\u012d doli pecheni po povodu teratoblastomy [Resection of the right lobe of the liver in teratoblastoma]. Vestn Khir Im I I Grek 1977;118."},{"key":"2025082710151765000_18.8.e265218.11","first-page":"25","article-title":"Combined chemotherapy of the metastases of testicular teratoblastomas","volume":"25","author":"Orel","year":"1979","journal-title":"Vopr Onkol"},{"key":"2025082710151765000_18.8.e265218.12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.humpath.2024.04.015","article-title":"Extragonadal germ cell tumors: A clinicopathologic study with emphasis on molecular features, clinical outcomes and associated secondary malignancies","volume":"148","author":"Abdulfatah","year":"2024","journal-title":"Hum Pathol"},{"key":"2025082710151765000_18.8.e265218.13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/PGP.0000000000000319","article-title":"Mature and Immature Solid Teratomas Involving Uterine Corpus, Cervix, and Ovary","volume":"36","author":"Stolnicu","year":"2017","journal-title":"Int J Gynecol Pathol"},{"key":"2025082710151765000_18.8.e265218.14","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70490-5"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:15:25Z","timestamp":1756314925000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":14,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8,27]]},"published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1136\/bcr-2025-265218"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265218","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}