{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:10:02Z","timestamp":1756372202025,"version":"3.44.0"},"reference-count":19,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,18]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Small-cell carcinomas of the genitourinary tract are high-grade neuroendocrine cancers with high metastatic potential. Penile cancer, though infrequent, is primarily squamous cell carcinomas.<\/jats:p>\n               <jats:p>We report the second case of neuroendocrine cancer of the penis in a man in the seventh decade of life who presented with an enlarged area on the dorsum of the penis, clinical stage IV T1bN3M0 (tumour 1b, node 3, metastases 0).<\/jats:p>\n               <jats:p>Neoadjuvant chemotherapy with cisplatin at 70\u2009mg\/m<jats:sup>2<\/jats:sup> on day 1 (D1) and etoposide at 80\u2009mg\/m<jats:sup>2<\/jats:sup> on D1\u20133 every 21 days, for three cycles was administered. Later, he underwent a partial penectomy. Consolidation with chemoradiotherapy employing weekly carboplatin (AUC of 2\u2009mg\/mL) was administered concurrently with 65\u2009Gy radiation therapy to the bilateral iliac and inguinal nodes. The patient\u2019s CT shows no evidence of disease 48 months after completing the treatment.<\/jats:p>","DOI":"10.1136\/bcr-2025-265257","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T21:30:29Z","timestamp":1751405429000},"page":"e265257","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Combined neuroendocrine carcinoma of the penis: clinical, pathological and therapeutic insights"],"prefix":"10.1136","volume":"18","author":[{"given":"Lesly Cinthya","family":"Palomino Escobar","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Vall d\u2019Hebron Institute of Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-2929","authenticated-orcid":false,"given":"Nely","family":"D\u00edaz-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Vall d\u2019Hebron Institute of Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Eugenia","family":"Semidey","sequence":"additional","affiliation":[{"name":"Department of Pathology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mast","sequence":"additional","affiliation":[{"name":"Department of Radiology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Trilla","sequence":"additional","affiliation":[{"name":"Department of Urology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Vall d\u2019Hebron Institute of Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Carles","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Vall d\u2019Hebron Institute of Oncology, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"2025082801484970000_18.7.e265257.1","doi-asserted-by":"crossref","DOI":"10.1200\/EDBK_430336","article-title":"Emerging Insights in Small-Cell Carcinoma of the Genitourinary Tract: From Diagnosis to Novel Therapeutic Horizons","volume":"44","author":"Liao","year":"2024","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"2025082801484970000_18.7.e265257.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.02.027"},{"key":"2025082801484970000_18.7.e265257.3","unstructured":"Brierley J , et al . 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