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In addition, we illustrate the importance of a holistic and multidisciplinary approach to both diagnosis and management for patient outcomes when such complexity arises.<\/jats:p>","DOI":"10.1136\/bcr-2025-265334","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T09:55:20Z","timestamp":1745661320000},"page":"e265334","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Moebius-plus: a severe congenital multiple cranial neuropathy syndrome"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-4187","authenticated-orcid":false,"given":"Jen O","family":"Lim","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, University of Cambridge, Cambridge, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Addenbrooke\u2019s Hospital, Cambridge, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Addenbrooke\u2019s Hospital, Cambridge, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,26]]},"reference":[{"key":"2025082701413464000_18.4.e265334.1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ejmg.2018.05.010","article-title":"Epidemiology of septo-optic dysplasia with focus on prevalence and maternal age - A EUROCAT study","volume":"61","author":"Garne","year":"2018","journal-title":"Eur J Med Genet"},{"key":"2025082701413464000_18.4.e265334.2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.125"},{"key":"2025082701413464000_18.4.e265334.3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100150068011"},{"key":"2025082701413464000_18.4.e265334.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2017-219590","article-title":"M\u00f6bius syndrome associated with obesity and precocious puberty","volume":"11","author":"De Silva","year":"2018","journal-title":"BMJ Case Rep"},{"key":"2025082701413464000_18.4.e265334.5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ajmg.a.20500","article-title":"Moebius sequence and hypogonadotrophic hypogonadism","volume":"123A","author":"Jennings","year":"2003","journal-title":"Am J Med Genet A"},{"key":"2025082701413464000_18.4.e265334.6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1442-200X.1993.tb03026.x","article-title":"Moebius syndrome associated with pituitary dwarfism and hypoplastic optic disc","volume":"35","author":"Hashimoto","year":"1993","journal-title":"Pediatr Int"},{"key":"2025082701413464000_18.4.e265334.7","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ajmg.a.60683","article-title":"Will the real Moebius syndrome please stand up? A systematic review of the literature and statistical cluster analysis of clinical features","volume":"179","author":"Bell","year":"2019","journal-title":"Am J Med Genet A"},{"key":"2025082701413464000_18.4.e265334.8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3928\/0191-3913-19800101-07","article-title":"Duane\u2019s retraction syndrome associated with optic nerve hypoplasia","volume":"17","author":"Denslow","year":"1980","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"2025082701413464000_18.4.e265334.9","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a000984","article-title":"An exome sequencing study of Moebius syndrome including atypical cases reveals an individual with CFEOM3A and a TUBB3 mutation","volume":"3","author":"Patel","year":"2017","journal-title":"Cold Spring Harb Mol Case Stud"},{"key":"2025082701413464000_18.4.e265334.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.05.018"},{"key":"2025082701413464000_18.4.e265334.11","article-title":"Moebius Syndrome: What We Know So Far","volume":"15","author":"Zaidi","year":"2023","journal-title":"Cureus"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:41:43Z","timestamp":1756284103000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,26]]},"published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1136\/bcr-2025-265334"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265334","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,4]]}}}