{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:32:02Z","timestamp":1778200322320,"version":"3.51.4"},"reference-count":10,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,7,7]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Primary urethral adenocarcinoma in females is extremely rare, comprising less than 1% of female genitourinary cancers. Due to its rarity, treatment guidelines are unclear, and most cases present at advanced stages with a poor prognosis. Our case demonstrates the potential for urethra-sparing surgery as an effective treatment option in selected patients. A woman in her late 60s presented with a 2\u2009cm urethral mass and haematuria. MRI revealed a lesion extending toward the vaginal introitus without invasion. She underwent wide local excision, and histopathology confirmed moderately differentiated urethral adenocarcinoma with immunohistochemical positivity for CDX-2, E-cadherin and cytokeratins 7 and 20. Given the complete resection, age and comorbidities, a multidisciplinary team recommended surveillance instead of radical surgery. At 12 months postoperatively, the patient remains recurrence-free and asymptomatic. Our case demonstrates that urethra-sparing surgery is a viable option in select patients. Individualised treatment approaches should be taken that balance oncological control with quality-of-life preservation.<\/jats:p>","DOI":"10.1136\/bcr-2025-265387","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:10:26Z","timestamp":1753161026000},"page":"e265387","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Urethral-sparing surgical management of primary urethral adenocarcinoma in a female patient with successful oncological outcome"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8953-6492","authenticated-orcid":false,"given":"Dayan","family":"Jacob","sequence":"first","affiliation":[{"name":"Urology, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramachandran","family":"Amitharaj","sequence":"additional","affiliation":[{"name":"Urology, Darlington Memorial Hospital, Darlington, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan","family":"Trichal","sequence":"additional","affiliation":[{"name":"Histopathology, County Durham and Darlington NHS Foundation Trust, Darlington, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"Urology, Darlington Memorial Hospital, Darlington, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"2025082800343629000_18.7.e265387.1","doi-asserted-by":"crossref","DOI":"10.3390\/medicina59010109","article-title":"Management of Primary Female Urethral Adenocarcinoma: Two Rare Case Reports and Literature Review","volume":"59","author":"Tian","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"2025082800343629000_18.7.e265387.2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.9963"},{"key":"2025082800343629000_18.7.e265387.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.03.044"},{"key":"2025082800343629000_18.7.e265387.4","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0022-5347(17)35707-5","article-title":"Bladder sparing surgery for locally advanced female urethral cancer","volume":"150","author":"Hedden","year":"1993","journal-title":"J Urol"},{"key":"2025082800343629000_18.7.e265387.5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0094-0143(21)00400-6","article-title":"Surgical treatment of female urethral carcinoma","volume":"19","author":"Narayan","year":"1992","journal-title":"Urol Clin North Am"},{"key":"2025082800343629000_18.7.e265387.6","first-page":"5404","article-title":"Management of adenocarcinoma of the female urethra: case report and brief review","volume":"17","author":"Ouzaid","year":"2010","journal-title":"Can J Urol"},{"key":"2025082800343629000_18.7.e265387.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.10.031"},{"key":"2025082800343629000_18.7.e265387.8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1148\/radiology.178.2.1898991","article-title":"Female urethra: MR imaging","volume":"178","author":"Hricak","year":"1991","journal-title":"Radiology"},{"key":"2025082800343629000_18.7.e265387.9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/bju.16334","article-title":"Urethral cancer: a comprehensive review endorsed by the Global Society of Rare Genitourinary Tumours","volume":"134","author":"Garc\u00eda-Perdomo","year":"2024","journal-title":"BJU Int"},{"key":"2025082800343629000_18.7.e265387.10","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.juro.2011.10.037","article-title":"Detailed histological investigation of the female urethra: application to radical cystectomy","volume":"187","author":"Hinata","year":"2012","journal-title":"J Urol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:34:44Z","timestamp":1756366484000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":10,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,21]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bcr-2025-265387"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265387","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}