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Prompt recognition of this syndrome, as well as accurate identification and classification of the associated neoplastic condition, are crucial.<\/jats:p>\n               <jats:p>This report describes the case of a woman diagnosed with PAVS secondary to stage IV non-small cell lung adenocarcinoma harbouring a Kirsten Rat Sarcoma viral homolog oncogene (KRAS) G12A mutation (p.Gly12Ala).<\/jats:p>","DOI":"10.1136\/bcr-2025-265443","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T19:05:24Z","timestamp":1756148724000},"page":"e265443","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Paraneoplastic acral vascular syndrome in a patient with non-small cell lung adenocarcinoma with KRAS G12A oncogenic mutation"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4819-2344","authenticated-orcid":false,"given":"Miriam","family":"Arroyo Bravo","sequence":"first","affiliation":[{"name":"Internal Medicine, Parc Taul\u00ed Hospital Universitari, Sabadell, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0079-8752","authenticated-orcid":false,"given":"Estefan\u00eda","family":"D\u00edaz-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Internal Medicine, Parc Taul\u00ed Hospital Universitari, Sabadell, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6953-8505","authenticated-orcid":false,"given":"Marina","family":"Sierra-Boada","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"},{"name":"Medical Oncology Department, Parc Taul\u00ed Hospital Universitari, Sabadell, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Villac\u00e9 Gallego","sequence":"additional","affiliation":[{"name":"Internal Medicine, Parc Taul\u00ed Hospital Universitari, Sabadell, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), Universitat Aut\u00f2noma de Barcelona, Sabadell, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"2025082512051520000_18.8.e265443.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1006054"},{"key":"2025082512051520000_18.8.e265443.2","doi-asserted-by":"publisher","DOI":"10.2217\/ijr.10.17"},{"key":"2025082512051520000_18.8.e265443.3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90760-1"},{"key":"2025082512051520000_18.8.e265443.4","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000047","article-title":"Digital ischemia associated with cancer: results from a cohort study","volume":"93","author":"Le Besnerais","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"2025082512051520000_18.8.e265443.5","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120474"},{"key":"2025082512051520000_18.8.e265443.6","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"2025082512051520000_18.8.e265443.7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115891","article-title":"Advances and challenges in the treatment of lung cancer","volume":"169","author":"Li","year":"2023","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"2025082512051520000_18.8.e265443.8","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01626"},{"key":"2025082512051520000_18.8.e265443.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1504688"},{"key":"2025082512051520000_18.8.e265443.10","doi-asserted-by":"crossref","unstructured":"Luo J , Ostrem J , Pellini B , et al . 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