{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:23:13Z","timestamp":1787656993540,"version":"build-2736575974"},"reference-count":28,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,8,13]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>Pott\u2019s puffy tumour (PPT) is a rare condition defined by subperiosteal abscess formation following osteomyelitis of the frontal bone. Complications can be severe and involve intracranial progression.<\/jats:p>\n                  <jats:p>\n                    Here, we present a rare case of a PPT due to an\n                    <jats:italic>Aggregatibacter aphrophilus<\/jats:italic>\n                    infection of odontogenic origin in a young adult patient with a history of bilateral cheilognathopalatoschisis. Due to the unusual location of the abscess, the diagnosis was initially missed, leading to a delay of more than 1\u2009month until adequate treatment. Odontogenic treatment was initiated as source control, external drainage of the abscess was performed and intravenous and later oral antibiotics were administered, which, despite relatively poor treatment adherence, ultimately led to adequate control of the infection without the need for further surgical intervention. The current case is the first report to highlight cleft palate\u2014and consequent poorer oral health\u2014as a potential predisposing condition for PPT.\n                  <\/jats:p>","DOI":"10.1136\/bcr-2025-265510","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:05:13Z","timestamp":1787655913000},"page":"e265510","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Pott\u2019s puffy tumour based on\n                    <i>Aggregatibacter aphrophilus<\/i>\n                    in an adult patient with bilateral cheilognathopalatoschisis"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-3271","authenticated-orcid":false,"given":"Sadaf","family":"Soloukey","sequence":"first","affiliation":[{"name":"Neurosurgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"BrainEcho Lab, Neuroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Hoefnagel","sequence":"additional","affiliation":[{"name":"Neurosurgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick","family":"de Vogel","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-7178","authenticated-orcid":false,"given":"Andries Paul","family":"Nagtegaal","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kleijn","sequence":"additional","affiliation":[{"name":"Neurosurgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026082504050505000_19.8.e265510.1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27757"},{"key":"2026082504050505000_19.8.e265510.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103529"},{"key":"2026082504050505000_19.8.e265510.3","article-title":"Pott\u2019s Puffy Tumor, a Forgotten Complication of Sinusitis: Report of Two Cases","volume":"15","author":"Jalali","year":"2023","journal-title":"Cureus"},{"key":"2026082504050505000_19.8.e265510.4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ajem.2007.11.038","article-title":"Pott\u2019s Puffy tumor after minor head trauma","volume":"26","author":"Martinez-Diaz","year":"2008","journal-title":"Am J Emerg Med"},{"key":"2026082504050505000_19.8.e265510.5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/01676830.2019.1573909","article-title":"Trauma-associated Pott\u2019s puffy tumor: an ophthalmologic perspective","volume":"39","author":"Hassan","year":"2020","journal-title":"Orbit"},{"key":"2026082504050505000_19.8.e265510.6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000090469","article-title":"Pott\u2019s puffy tumor: a rare complication of mastoiditis","volume":"42","author":"Khan","year":"2006","journal-title":"Pediatr Neurosurg"},{"key":"2026082504050505000_19.8.e265510.7","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1097\/SCS.0000000000008010","article-title":"Pott Puffy Tumor Caused by Dental Infection: A Case Report and Literature Review","volume":"33","author":"Yang","year":"2022","journal-title":"J Craniofac Surg"},{"key":"2026082504050505000_19.8.e265510.8","doi-asserted-by":"crossref","first-page":"NP186","DOI":"10.1177\/0145561320952203","article-title":"Odontogenic Sinusitis-Associated Pott\u2019s Puffy Tumor: A Case Report and Literature Review","volume":"101","author":"Min","year":"2022","journal-title":"Ear Nose Throat J"},{"key":"2026082504050505000_19.8.e265510.9","first-page":"143","article-title":"The Pott puffy tumor revisited: neurosurgical implications of this unforgotten entity. Case report and review of the literature","volume":"105","author":"Kombogiorgas","year":"2006","journal-title":"J Neurosurg"},{"key":"2026082504050505000_19.8.e265510.10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1177\/014556130208100911","article-title":"Intracranial complications of sinusitis: a 15-year review of 39 cases","volume":"81","author":"Younis","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"2026082504050505000_19.8.e265510.11","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13040587","article-title":"A Systematic Review of Intracranial Complications in Adults with Pott Puffy Tumor over Four Decades","volume":"13","author":"Sideris","year":"2023","journal-title":"Brain Sci"},{"key":"2026082504050505000_19.8.e265510.12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5144\/0256-4947.2012.26.5.1116","article-title":"Pott puffy tumor: a rare complication of sinusitis","volume":"33","author":"ur Rehman","year":"2013","journal-title":"Ann Saudi Med"},{"key":"2026082504050505000_19.8.e265510.13","doi-asserted-by":"crossref","DOI":"10.7812\/TPP\/15-157","article-title":"Image Diagnosis: Pott Puffy Tumor","volume":"20","author":"Apostolakos","year":"2016","journal-title":"Perm J"},{"key":"2026082504050505000_19.8.e265510.14","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjz099","article-title":"Potts puffy tumour: a rare but important diagnosis","volume":"2019","author":"Hasan","year":"2019","journal-title":"J Surg Case Rep"},{"key":"2026082504050505000_19.8.e265510.15","article-title":"Extensive Frontoparietal Abscess: Complication of Frontal Sinusitis (Pott\u2019s Puffy Tumor)","volume":"2014","author":"Lauria","year":"2014","journal-title":"Case Rep Otolaryngol"},{"key":"2026082504050505000_19.8.e265510.16","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/coa.12538","article-title":"Minimally invasive treatment of patients with Pott\u2019s puffy tumour with or without endocranial extension - a case series of six patients: Our Experience","volume":"41","author":"van der Poel","year":"2016","journal-title":"Clin Otolaryngol"},{"key":"2026082504050505000_19.8.e265510.17","doi-asserted-by":"crossref","unstructured":"Botero JE , Rodr\u00edguez-Medina C , Mart\u00ednez-Pab\u00f3n MC , et al . Chapter 43 - aggregatibacter. In: Tang Y-W , Hindiyeh MY , Liu D , eds. Molecular Medical Microbiology (Third Edition). Academic Press, 2024: 905\u201314.","DOI":"10.1016\/B978-0-12-818619-0.00149-0"},{"key":"2026082504050505000_19.8.e265510.18","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jiac.2021.02.005","article-title":"A rare case of voluminous brain abscess due to Actinomyces meyeri and Aggregatibacter aphrophilus: is there any evidence for a prolonged antibiotic oral relay?","volume":"27","author":"Altdorfer","year":"2021","journal-title":"J Infect Chemother"},{"key":"2026082504050505000_19.8.e265510.19","doi-asserted-by":"crossref","first-page":"105360","DOI":"10.1016\/j.archoralbio.2022.105360","article-title":"The connection between brain abscess and odontogenic infections: A systematic review","volume":"135","author":"Lisboa","year":"2022","journal-title":"Arch Oral Biol"},{"key":"2026082504050505000_19.8.e265510.20","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1007\/s00784-023-04976-6","article-title":"Cerebral abscesses with odontogenic origin: a population-based cohort study","volume":"27","author":"Jespersen","year":"2023","journal-title":"Clin Oral Investig"},{"key":"2026082504050505000_19.8.e265510.21","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofv031","article-title":"A Case of Aggregatibacter aphrophilus Multiple Abscess","volume":"2","author":"Belkacem","year":"2015","journal-title":"Open Forum Infect Dis"},{"key":"2026082504050505000_19.8.e265510.22","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02407-21","article-title":"Culture on Selective Media and Amplicon-Based Sequencing of 16S rRNA from Spontaneous Brain Abscess-the View from the Diagnostic Laboratory","volume":"10","author":"Andersen","year":"2022","journal-title":"Microbiol Spectr"},{"key":"2026082504050505000_19.8.e265510.23","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.1092809","article-title":"Dental caries and periodontitis risk factors in cleft lip and palate patients","volume":"10","author":"Wu","year":"2022","journal-title":"Front Pediatr"},{"key":"2026082504050505000_19.8.e265510.24","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1159455","article-title":"Characterizing the microbiota of cleft lip and palate patients: a comprehensive review","volume":"13","author":"Gershater","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"2026082504050505000_19.8.e265510.25","doi-asserted-by":"crossref","DOI":"10.1186\/s40510-019-0265-1","article-title":"Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients","volume":"20","author":"Funahashi","year":"2019","journal-title":"Prog Orthod"},{"key":"2026082504050505000_19.8.e265510.26","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870040112026"},{"key":"2026082504050505000_19.8.e265510.27","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1989.01860280040014"},{"key":"2026082504050505000_19.8.e265510.28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0385-8146(99)00066-8","article-title":"Maxillary sinus development and sinusitis in patients with cleft lip and palate","volume":"27","author":"Suzuki","year":"2000","journal-title":"Auris Nasus Larynx"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:05:17Z","timestamp":1787655917000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8,25]]},"published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1136\/bcr-2025-265510"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265510","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}