{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:40:16Z","timestamp":1756363216612,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,5]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>The uvea is the most common site for ocular metastasis. Within this, the choroid is commonly involved as compared with the iris and the ciliary body. This is due to the distribution of blood supply, which is greater in the choroid than in the iris and ciliary body. Ocular metastasis mostly occurs from breast and lung cancer. Choroidal metastasis from thyroid carcinoma is rare. The gold standard test for diagnosis of choroidal metastasis is fluorescein angiography. We present the case of a man in his early 30s who reported a concern of diminished vision in the right eye for 2 weeks. Fundus examination revealed a localised elevated hypopigmented lesion superiorly and exudative retinal detachment inferiorly. The patient has already been diagnosed with stage 4 medullary thyroid carcinoma, underwent thyroidectomy and is currently on chemotherapy. MRI showed widely scattered metastatic lesions in the brain, orbit, liver, lungs and pancreas.<\/jats:p>","DOI":"10.1136\/bcr-2025-265540","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T05:10:33Z","timestamp":1753161033000},"page":"e265540","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Choroidal metastases and exudative retinal detachment in medullary thyroid carcinoma"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9087-1348","authenticated-orcid":false,"given":"Anjali","family":"Shukla","sequence":"first","affiliation":[{"name":"Ophthalmology, Mata Gujri Memorial Medical College, Kishanganj, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5620-9869","authenticated-orcid":false,"given":"Kamal Nayan","family":"Biswas","sequence":"additional","affiliation":[{"name":"Ophthalmology, Mata Gujri Memorial Medical College, Kishanganj, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Kumari","sequence":"additional","affiliation":[{"name":"Ophthalmology, Mata Gujri Memorial Medical College, Kishanganj, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh Kumar","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Ophthalmology, Mata Gujri Memorial Medical College, Kishanganj, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"2025082723024942000_18.7.e265540.1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000336977","article-title":"2012 European thyroid association guidelines for metastatic medullary thyroid cancer","volume":"1","author":"Schlumberger","year":"2012","journal-title":"Eur Thyroid J"},{"key":"2025082723024942000_18.7.e265540.2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3341\/kjo.2013.27.3.215","article-title":"Papillary thyroid carcinoma: bilateral choroidal metastases with extrascleral extension","volume":"27","author":"Kiratli","year":"2013","journal-title":"Korean J Ophthalmol"},{"key":"2025082723024942000_18.7.e265540.3","article-title":"Choroidal metastasis from follicular cell thyroid carcinoma masquerading as circumscribed choroidal haemangioma","volume":"2014","author":"Papastefanou","year":"2014","journal-title":"Case Rep Oncol Med"},{"key":"2025082723024942000_18.7.e265540.4","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0021"},{"key":"2025082723024942000_18.7.e265540.5","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.annonc.2021.08.1987","article-title":"Significant response of medullary thyroid cancer choroidal metastases to highly selective RET inhibitor selpercatinib: a case report","volume":"32","author":"Matrone","year":"2021","journal-title":"Ann Oncol"},{"key":"2025082723024942000_18.7.e265540.6","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000131"},{"key":"2025082723024942000_18.7.e265540.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30148-1"},{"key":"2025082723024942000_18.7.e265540.8","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1089\/thy.2014.0511","article-title":"Unusual Case of Papillary Thyroid Carcinoma with Choroidal Metastasis","volume":"25","author":"Makhija","year":"2015","journal-title":"Thyroid"},{"key":"2025082723024942000_18.7.e265540.9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.oftale.2019.10.006","article-title":"Choroidal metastases as initial manifestation of a papillary thyroid carcinoma: A case report","volume":"95","author":"Chac\u00f3n Gonz\u00e1lez","year":"2020","journal-title":"Archivos de La Sociedad Espa\u00f1ola de Oftalmolog\u00eda (English Edition)"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265540","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:02:57Z","timestamp":1756360977000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":9,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,21]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bcr-2025-265540"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265540","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}