{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:36:54Z","timestamp":1783129014419,"version":"3.54.6"},"reference-count":37,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,17]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>This case describes a man in his 70s with a 12-year history of bullous pemphigoid (BP) and recurrent prostate cancer, both diagnosed in the same year. Initially managed with active surveillance, his prostate cancer progressed, requiring hormonal therapy, surgery, and, eventually due to recurrence, salvage radiation therapy (RT). Concurrently, his BP, characterised by blistering skin lesions, was managed with corticosteroids, azathioprine and methotrexate, though full control of disease activity was difficult. Following salvage RT and androgen deprivation therapy, his prostate-specific antigen (PSA) levels and BP improved significantly, leading to prostate cancer remission and near resolution of his BP.<\/jats:p>\n               <jats:p>The patient continues methotrexate, with stable PSA and only minor localised BP activity. The temporal relationship between his prostate cancer and BP, including their simultaneous onset, recurrence and remission, suggests a possible paraneoplastic link. Understanding this relationship is crucial for accurate prognosis and effective treatment for men with prostate cancer and associated paraneoplastic syndromes.<\/jats:p>","DOI":"10.1136\/bcr-2025-265542","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T13:25:11Z","timestamp":1752153911000},"page":"e265542","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Improvement of bullous pemphigoid following salvage radiation in PSA-recurrent prostate cancer: a potential paraneoplastic association"],"prefix":"10.1136","volume":"18","author":[{"given":"Michael Shen","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna Aline","family":"Culton","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan Everett","family":"Fecteau","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA"},{"name":"Duke Cancer Institute Center for Prostate and Urologic Cancers, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA"},{"name":"Duke Cancer Institute Center for Prostate and Urologic Cancers, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"2025082804330889000_18.7.e265542.1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0099"},{"key":"2025082804330889000_18.7.e265542.2","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.jaad.2018.03.043","article-title":"Risk factors for death and survival in paraneoplastic pemphigus associated with hematologic malignancies in adults","volume":"80","author":"Ouedraogo","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2025082804330889000_18.7.e265542.3","doi-asserted-by":"publisher","DOI":"10.1159\/000224860"},{"key":"2025082804330889000_18.7.e265542.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-237115","article-title":"Dermatological manifestation of metastatic prostate cancer","volume":"13","author":"Gibb","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2025082804330889000_18.7.e265542.5","first-page":"9262","article-title":"Paraneoplastic dermatomyositis and prostate cancer: Myopathy regression under cancer-directed therapy","volume":"13","author":"Miranda Baleiras","year":"2021","journal-title":"Dermatol Reports"},{"key":"2025082804330889000_18.7.e265542.6","doi-asserted-by":"crossref","first-page":"5716","DOI":"10.2340\/00015555-3457","article-title":"A Systematic Review of Drug-Induced Pemphigoid","volume":"100","author":"Verheyden","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"2025082804330889000_18.7.e265542.7","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2490-14-88","article-title":"Malignant acanthosis nigricans associated with prostate cancer: a case report","volume":"14","author":"Kubicka-Wo\u0142kowska","year":"2014","journal-title":"BMC Urol"},{"key":"2025082804330889000_18.7.e265542.8","unstructured":"DeVita VT , Lawrence TS , Rosenberg SA . 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