{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:40:09Z","timestamp":1756370409820,"version":"3.44.0"},"reference-count":9,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,5,13]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>A man in his mid-20s presented with a 5-month history of bilateral lower limb weakness and wasting along with bladder symptoms and erectile dysfunction. Additionally, he had binocular diplopia and progressive drooping of both eyelids. His clinical presentation was suggestive of bilateral third cranial nerve involvement with lumbosacral polyradiculopathy. Initial treatment with steroids for suspected idiopathic lumbosacral polyradiculopathy syndrome proved ineffective, as his symptoms progressively worsened without other systemic manifestations. We diagnosed a rare and treatable neurological condition, primary neurolymphomatosis, presenting as lumbosacral polyradiculopathy with bilateral third cranial nerve involvement. A definitive diagnosis was established only after nerve root biopsy, highlighting the crucial role of biopsy in confirming the diagnosis. Our case underscores the importance of early consideration for an invasive nerve root biopsy, enabling prompt treatment and an improved prognosis.<\/jats:p>","DOI":"10.1136\/bcr-2025-265566","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T23:25:35Z","timestamp":1748301935000},"page":"e265566","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Primary neurolymphomatosis presenting as paraparesis and diplopia in a young man"],"prefix":"10.1136","volume":"18","author":[{"given":"Shiny","family":"Joy","sequence":"first","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shariq Ahmad","family":"Shah","sequence":"additional","affiliation":[{"name":"Neuroradiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-8882","authenticated-orcid":false,"given":"Mamta Bhushan","family":"Singh","sequence":"additional","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailesh B","family":"Gaikwad","sequence":"additional","affiliation":[{"name":"Neuroradiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaishali","family":"Suri","sequence":"additional","affiliation":[{"name":"Neuropathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghav","family":"Singla","sequence":"additional","affiliation":[{"name":"Neurosurgery, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Bakhshi","sequence":"additional","affiliation":[{"name":"Oncology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"2025082801252862000_18.5.e265566.1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3988\/jcn.2016.12.3.274","article-title":"The Diagnostic Dilemma of Neurolymphomatosis","volume":"12","author":"Shree","year":"2016","journal-title":"J Clin Neurol"},{"doi-asserted-by":"publisher","key":"2025082801252862000_18.5.e265566.2","DOI":"10.1177\/014107689408700915"},{"doi-asserted-by":"publisher","key":"2025082801252862000_18.5.e265566.3","DOI":"10.1182\/blood-2009-12-258210"},{"doi-asserted-by":"publisher","key":"2025082801252862000_18.5.e265566.4","DOI":"10.1093\/neuonc\/5.2.104"},{"key":"2025082801252862000_18.5.e265566.5","doi-asserted-by":"crossref","first-page":"103017","DOI":"10.1016\/j.msard.2021.103017","article-title":"Two cases of myelin oligodendrocyte glycoprotein antibody-associated disease presenting with Cauda Equina Syndrome without conus myelitis","volume":"52","author":"Kang","year":"2021","journal-title":"Mult Scler Relat Disord"},{"doi-asserted-by":"publisher","key":"2025082801252862000_18.5.e265566.6","DOI":"10.1200\/JCO.2002.11.013"},{"doi-asserted-by":"publisher","key":"2025082801252862000_18.5.e265566.7","DOI":"10.1016\/0002-9343(79)91065-9"},{"doi-asserted-by":"publisher","key":"2025082801252862000_18.5.e265566.8","DOI":"10.1097\/MNM.0b013e3283561881"},{"key":"2025082801252862000_18.5.e265566.9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s44276-024-00053-x","article-title":"The natural history of neurolymphomatosis","volume":"2","author":"Xu","year":"2024","journal-title":"BJC Rep"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:25:39Z","timestamp":1756369539000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,26]]},"published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1136\/bcr-2025-265566"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265566","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,5]]}}}