{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:25:22Z","timestamp":1776468322746,"version":"3.51.2"},"reference-count":28,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"unspecified","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,12,11]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Rosai-Dorfman-Destombes disease (RDD) is a rare, benign histiocytic disorder, most often involving lymph nodes but showing extranodal manifestations in nearly 50% of cases, particularly in the skin and upper respiratory tract. A hallmark histological feature is emperipolesis\u2014large CD68+ and\u2009S100+ histiocytes containing intact inflammatory cells. We report a unique case of bilateral testicular RDD in a man with prior extranodal marginal zone lymphoma of the lungs. Three years after lymphoma remission, he presented with bilateral testicular enlargement. Ultrasound and positron emission tomography\/CT showed diffuse hypoechoic parenchyma with metabolic activity suggestive of malignancy. Bilateral orchiectomy revealed tan-yellow, fleshy masses infiltrating the testicular parenchyma. Histology confirmed RDD with emperipolesis and S100+\/CD68+\/CD1a\u2212 phenotype. Testicular RDD is extremely uncommon, with only ~15 cases described to date, and its association with haematological malignancy remains poorly understood. Recognition of this entity is essential to avoid unnecessary oncological treatment.<\/jats:p>","DOI":"10.1136\/bcr-2025-265657","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:45:36Z","timestamp":1767789936000},"page":"e265657","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Rosai-Dorfman disease mimicking testicular malignancy in a patient with marginal zone lymphoma of the lung"],"prefix":"10.1136","volume":"19","author":[{"given":"Efrain","family":"Lee-Diaz","sequence":"first","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria Claire","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Pathology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pathology, UCHealth Highlands Ranch Hospital, Highlands Ranch, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenggang","family":"Pan","sequence":"additional","affiliation":[{"name":"Pathology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-3001","authenticated-orcid":false,"given":"Francisco G","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Pathology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"2026010704452959000_19.1.e265657.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690636"},{"key":"2026010704452959000_19.1.e265657.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-839753"},{"key":"2026010704452959000_19.1.e265657.3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0053"},{"key":"2026010704452959000_19.1.e265657.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00311-1"},{"key":"2026010704452959000_19.1.e265657.5","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.55"},{"key":"2026010704452959000_19.1.e265657.6","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.219626"},{"key":"2026010704452959000_19.1.e265657.7","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMcpc2402486","article-title":"Case 30-2024: A 45-Year-Old Woman with Kidney Lesions and Lytic Bone Disease","volume":"391","author":"Chen","year":"2024","journal-title":"N Engl J Med"},{"key":"2026010704452959000_19.1.e265657.8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2169\/internalmedicine.56.7609","article-title":"Rosai-Dorfman Disease of the Lung Overlapping with IgG4-related Disease: The Difficulty in Its Differential Diagnosis","volume":"56","author":"Hasegawa","year":"2017","journal-title":"Intern Med"},{"key":"2026010704452959000_19.1.e265657.9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000833","article-title":"Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease","volume":"6","author":"Morgan","year":"2010","journal-title":"PLoS Genet"},{"key":"2026010704452959000_19.1.e265657.10","doi-asserted-by":"publisher","DOI":"10.1111\/his.12494"},{"key":"2026010704452959000_19.1.e265657.11","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.clinimag.2016.09.006","article-title":"Abdominal and pelvic manifestations of Rosai-Dorfman disease: a review of four cases","volume":"40","author":"Karajgikar","year":"2016","journal-title":"Clin Imaging"},{"key":"2026010704452959000_19.1.e265657.12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196604282741702"},{"key":"2026010704452959000_19.1.e265657.13","unstructured":"De Guzman R , Montpetit VJ , Barr JR , et al . 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