{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:39:40Z","timestamp":1767721180320,"version":"3.48.0"},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,12,12]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Glomus tumours are uncommon, typically benign neoplasms of specialised dermal thermoregulatory structures known as glomus bodies. Wide local excision is the gold standard management for such tumours with good recurrence-free outcomes. Rarely, they may exhibit malignant and metastatic behaviour. The efficacy of systemic treatments to manage widespread or metastatic disease has been trialled with varying degrees of success but remains poorly understood.<\/jats:p>\n                  <jats:p>This case report describes a cutaneous glomus tumour in a female patient. Despite prompt wide local excision of the primary lesion and subsequent nodal recurrence, the patient developed metastatic disease that failed to respond to taxane chemotherapy but was stabilised for several months with selective internal radiation therapy and doxorubicin. She passed away shortly after developing widespread abdominal and bony metastases.<\/jats:p>\n                  <jats:p>This case highlights the potentially aggressive recurrence of glomus tumours, the importance of close follow-up and the challenges of treating lesser understood cancers.<\/jats:p>","DOI":"10.1136\/bcr-2025-265756","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:35:15Z","timestamp":1767720915000},"page":"e265756","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Unusually aggressive malignant glomus tumour of cutaneous origin"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3769-615X","authenticated-orcid":false,"given":"Gabrielle","family":"Moe","sequence":"first","affiliation":[{"name":"Oncology, Queen Elizabeth Hospital, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Sherriff","sequence":"additional","affiliation":[{"name":"Oncology, Queen Elizabeth Hospital, Birmingham, UK"},{"name":"Queen Elizabeth Hospital Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillipe","family":"Taniere","sequence":"additional","affiliation":[{"name":"Queen Elizabeth Hospital Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"2026010609350487000_19.1.e265756.1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.5858\/2008-132-1448-GT","article-title":"Glomus tumor","volume":"132","author":"Gombos","year":"2008","journal-title":"Arch Pathol Lab Med"},{"key":"2026010609350487000_19.1.e265756.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200101000-00001"},{"key":"2026010609350487000_19.1.e265756.3","doi-asserted-by":"crossref","DOI":"10.1097\/GOX.0000000000000144","article-title":"Glomus tumors and neurofibromatosis: a newly recognized association","volume":"2","author":"Harrison","year":"2014","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026010609350487000_19.1.e265756.4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.5414\/NP300989","article-title":"Intraneural glomus tumor of \u201cuncertain malignant potential\u201d and with BRAF mutation in the median nerve - an unusual case","volume":"36","author":"Dahlin","year":"2017","journal-title":"Clin Neuropathol"},{"key":"2026010609350487000_19.1.e265756.5","doi-asserted-by":"crossref","DOI":"10.1093\/jscr\/rjab641","article-title":"A case of malignant glomus tumor (glomangiosarcoma) of the nasal cavity","volume":"2022","author":"Alhroub","year":"2022","journal-title":"J Surg Case Rep"},{"key":"2026010609350487000_19.1.e265756.6","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/1758573214522019","article-title":"Glomus tumour of the elbow: a case of mistaken identity","volume":"6","author":"Zreik","year":"2014","journal-title":"Shoulder Elbow"},{"key":"2026010609350487000_19.1.e265756.7","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-212963","article-title":"A recurred subungual glomus tumour of the thumb","volume":"2016","author":"Jalan","year":"2016","journal-title":"BMJ Case Rep"},{"key":"2026010609350487000_19.1.e265756.8","doi-asserted-by":"crossref","DOI":"10.1097\/GOX.0000000000001219","article-title":"Glomangiosarcoma Arising from a Prior Biopsy Site","volume":"5","author":"Maselli","year":"2017","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"2026010609350487000_19.1.e265756.9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12957-014-0423-3","article-title":"Malignant glomus tumor of the lung with multiple metastasis: a rare case report","volume":"13","author":"Wang","year":"2015","journal-title":"World J Surg Oncol"},{"key":"2026010609350487000_19.1.e265756.10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.21037\/acr-21-72","article-title":"Rare malignant glomus tumor of the esophagus with pulmonary metastasis: a case report","volume":"6","author":"Xiao","year":"2022","journal-title":"AME Case Rep"},{"key":"2026010609350487000_19.1.e265756.11","article-title":"Glomus Extradigital Tumor: A Case Report of an Extradigital Glomus Tumor on the Wrist and Comprehensive Review of Glomus Tumors","volume":"15","author":"Cohen","year":"2023","journal-title":"Cureus"},{"key":"2026010609350487000_19.1.e265756.12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13569-020-00142-8","article-title":"Glomus tumors with malignant features of the extremities: a case series","volume":"10","author":"Wood","year":"2020","journal-title":"Clin Sarcoma Res"},{"key":"2026010609350487000_19.1.e265756.13","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.3889\/oamjms.2019.610","article-title":"Low-Grade Malignancy Glomus Tumor in a Setting of Multiple Glomus Tumors - Case Report","volume":"7","author":"Vasilevska-Nikodinovska","year":"2019","journal-title":"Open Access Maced J Med Sci"},{"key":"2026010609350487000_19.1.e265756.14","first-page":"339","article-title":"Lesser Sac Glomangiosarcoma With Simultaneous Liver And Lymph Nodes Metastases Mimicking Small Bowel Gastrointestinal Stromal Tumor; Immunohistochemistry And Empirical Chemotherapy","volume":"12","author":"Negahi","year":"2019","journal-title":"Int Med Case Rep J"},{"key":"2026010609350487000_19.1.e265756.15","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2012-007618","article-title":"Clinically malignant atypical glomus tumour","volume":"2013","author":"Binesh","year":"2013","journal-title":"BMJ Case Rep"},{"key":"2026010609350487000_19.1.e265756.16","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.joscr.2024.01.001","article-title":"Metastatic malignant glomus tumor resistant to pazopanib, a multikinase inhibitor: A case report and review of literature","volume":"3","author":"Kawaguchi","year":"2024","journal-title":"JOS Case Reports"},{"key":"2026010609350487000_19.1.e265756.17","first-page":"4","article-title":"Response to chemotherapy with epirubicin plus ifosfamide and to tyrosine kinase inhibitor in a metastatic malignant glomus tumor","volume":"8","author":"Colia","year":"2022","journal-title":"J Case Rep Images Oncology"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:35:24Z","timestamp":1767720924000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,6]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/bcr-2025-265756"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265756","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}