{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:40:10Z","timestamp":1756363210411,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,5,19]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>A man in his mid-80s with a history of heart failure presented with new onset cough, dyspnoea, opacities\/infiltrates and oxygen requirement after 16 days of daptomycin use for methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> bacteraemia. His symptoms did not respond to appropriate diuresis. He experienced an improvement in symptoms and eventually resolution after discontinuation of daptomycin and replacement with vancomycin for continued treatment of his bacteraemia. He was determined to have probable daptomycin-induced acute eosinophilic pneumonia, a rare side effect of daptomycin use, based on clinical presentation, peripheral eosinophilia correlated with daptomycin use, risk factors and resolution of symptoms following discontinuation of daptomycin.<\/jats:p>","DOI":"10.1136\/bcr-2025-265819","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:16:07Z","timestamp":1749096967000},"page":"e265819","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Daptomycin-induced pulmonary eosinophilia: early identification of antibiotic side effects"],"prefix":"10.1136","volume":"18","author":[{"given":"Talya","family":"Jaffe","sequence":"first","affiliation":[{"name":"The University of New Mexico School of Medicine, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Lukes","sequence":"additional","affiliation":[{"name":"The University of New Mexico Department of Internal Medicine, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"McCraw","sequence":"additional","affiliation":[{"name":"The University of New Mexico Department of Internal Medicine, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"The University of New Mexico Department of Internal Medicine, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bode","sequence":"additional","affiliation":[{"name":"The University of New Mexico Department of Internal Medicine, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2589-9468","authenticated-orcid":false,"given":"Wendy","family":"Gerstein","sequence":"additional","affiliation":[{"name":"Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA"},{"name":"Internal Medicine, New Mexico VA Health Care System, Albuquerque, New Mexico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"2025082723022908000_18.6.e265819.1","doi-asserted-by":"crossref","DOI":"10.1186\/s13756-016-0158-8","article-title":"Daptomycin-induced eosinophilic pneumonia - a systematic review","volume":"5","author":"Uppal","year":"2016","journal-title":"Antimicrob Resist Infect Control"},{"key":"2025082723022908000_18.6.e265819.2","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofac577","article-title":"Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm","volume":"9","author":"Pham","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2025082723022908000_18.6.e265819.3","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics10040446","article-title":"Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection","volume":"10","author":"Soldevila-Boixader","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"2025082723022908000_18.6.e265819.4","article-title":"Daptomycin-Induced Acute Eosinophilic Pneumonia","volume":"13","author":"Portalatin","year":"2021","journal-title":"Cureus"},{"key":"2025082723022908000_18.6.e265819.5","doi-asserted-by":"crossref","unstructured":"Gerts N , Nathan R , Tabet A , et al . A Case of Daptomycin-Induced Eosinophilic Pneumonia. AIM Clinical Cases 2023;2. doi:10.7326\/aimcc.2022.0827","DOI":"10.7326\/aimcc.2022.0827"},{"key":"2025082723022908000_18.6.e265819.6","article-title":"Daptomycin-induced Acute Eosinophilic Pneumonia","volume":"10","author":"Kumar","year":"2018","journal-title":"Cureus"},{"key":"2025082723022908000_18.6.e265819.7","doi-asserted-by":"publisher","DOI":"10.1086\/430352"},{"key":"2025082723022908000_18.6.e265819.8","unstructured":"Center for Drug Evaluation and Research . \u201cEosinophilic pneumonia associated with the use of cubicin.\u201d u.s. food and drug administration, fda. Available: www.fda.gov\/drugs\/postmarket-drugsafetyinformation-patients-and-providers\/fda-drug-safety-communication-eosinophilicpneumoniaassociated-use-cubicin-daptomycin [Accessed 20 Jan 2025]."},{"key":"2025082723022908000_18.6.e265819.9","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939522"},{"key":"2025082723022908000_18.6.e265819.10","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2013.805427"},{"key":"2025082723022908000_18.6.e265819.11","doi-asserted-by":"publisher","DOI":"10.2165\/11597460-000000000-00000"},{"key":"2025082723022908000_18.6.e265819.12","article-title":"Daptomycin-Induced Pulmonary Toxicity: A Case Series","volume":"15","author":"Patel","year":"2023","journal-title":"Cureus"},{"key":"2025082723022908000_18.6.e265819.13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jiac.2016.09.001","article-title":"Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions and a review of the literature","volume":"23","author":"Hirai","year":"2017","journal-title":"J Infect Chemother"},{"key":"2025082723022908000_18.6.e265819.14","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofac065","article-title":"Eosinophilic Syndromes Associated With Daptomycin Use: Re-exposure Hypersensitivity Pneumonitis and Prior Peripheral Eosinophilia","volume":"9","author":"West","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2025082723022908000_18.6.e265819.15","doi-asserted-by":"crossref","first-page":"635A","DOI":"10.1378\/chest.2247139","article-title":"Acute Eosinophilic Pneumonia Due to Exposure to Daptomycin Leading to Ventilator-Dependent Respiratory Failure","volume":"148","author":"Neyra","year":"2015","journal-title":"Chest"},{"key":"2025082723022908000_18.6.e265819.16","doi-asserted-by":"crossref","first-page":"102501","DOI":"10.1016\/j.jiac.2024.08.016","article-title":"Association between age and onset of daptomycin-induced adverse events using the U.S. food and drug administration adverse event reporting system","volume":"31","author":"Shiraishi","year":"2025","journal-title":"J Infect Chemother"},{"key":"2025082723022908000_18.6.e265819.17","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25122888","article-title":"Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches","volume":"25","author":"Karaman","year":"2020","journal-title":"Molecules"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-265819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:02:39Z","timestamp":1756360959000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-265819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,4]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/bcr-2025-265819"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-265819","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}