{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T20:10:09Z","timestamp":1756325409503,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,5]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>\n                  <jats:italic>Klebsiella pneumoniae<\/jats:italic> is emerging as a pathogen of global concern due to an increasing incidence of hypervirulent pathotypes causing life-threatening infections, including infective endocarditis (IE). A man in his 30s who was previously fit and well, presented to our eye casualty with headaches, papilloedema and fever. Blood cultures grew <jats:italic>K. pneumoniae<\/jats:italic> and transthoracic echocardiography detected IE of the aortic and mitral valves. Fluorodeoxyglucose positron emission tomography revealed focal increased accumulation at the right side of the prostate. The patient was treated for <jats:italic>K. pneumoniae<\/jats:italic> subacute IE of the aortic and mitral valves, originating from asymptomatic prostatitis. Our case highlights that young, healthy, immunocompetent patients can develop IE from <jats:italic>K. pneumoniae<\/jats:italic>. It also demonstrates that papilloedema can be a presenting sign of this disease. To our knowledge, there are no previous reports of IE presenting with papilloedema.<\/jats:p>","DOI":"10.1136\/bcr-2025-266152","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T14:35:31Z","timestamp":1751034931000},"page":"e266152","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Klebsiella pneumoniae<\/i> infective endocarditis originating from asymptomatic prostatitis presenting with papilloedema"],"prefix":"10.1136","volume":"18","author":[{"given":"Nuala","family":"Pepper","sequence":"first","affiliation":[{"name":"Foundation Programme, United Lincolnshire Hospitals NHS Trust, Lincoln, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Reuber","sequence":"additional","affiliation":[{"name":"Neurology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Foster","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Acute Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"2025082712310599000_18.6.e266152.1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0140-6736(24)01098-5","article-title":"Infective endocarditis","volume":"404","author":"Li","year":"2024","journal-title":"Lancet"},{"key":"2025082712310599000_18.6.e266152.2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/1120009X.2021.1888025","article-title":"Infective endocarditis by Klebsiella species: a systematic review","volume":"33","author":"Ioannou","year":"2021","journal-title":"J Chemother"},{"doi-asserted-by":"publisher","key":"2025082712310599000_18.6.e266152.3","DOI":"10.1080\/14787210.2019.1555470"},{"key":"2025082712310599000_18.6.e266152.4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4103\/0301-4738.60098","article-title":"Ophthalmoparesis, papillitis and premacular hemorrhage in a case with endocarditis: A rare presentation of Brucellosis","volume":"58","author":"Sahin","year":"2010","journal-title":"Indian J Ophthalmol"},{"doi-asserted-by":"publisher","key":"2025082712310599000_18.6.e266152.5","DOI":"10.1016\/S0002-9394(02)02062-7"},{"key":"2025082712310599000_18.6.e266152.6","doi-asserted-by":"crossref","DOI":"10.1007\/s11886-021-01542-y","article-title":"18F-FDG PET\/CT in Infective Endocarditis: Indications and Approaches for Standardization","volume":"23","author":"Ten Hove","year":"2021","journal-title":"Curr Cardiol Rep"},{"key":"2025082712310599000_18.6.e266152.7","first-page":"114","article-title":"Acute Bacterial Prostatitis: Diagnosis and Management","volume":"93","author":"Coker","year":"2016","journal-title":"Am Fam Physician"},{"key":"2025082712310599000_18.6.e266152.8","first-page":"255","article-title":"An update on the role of 18F-FDG-PET\/CT in major infectious and inflammatory diseases","volume":"9","author":"Kung","year":"2019","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"2025082712310599000_18.6.e266152.9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jiac.2023.09.028","article-title":"A case of hypervirulent K1-ST23 Klebsiella pneumoniae endocarditis and papillary muscle rupture secondary to multiple site abscesses","volume":"30","author":"Kawase","year":"2024","journal-title":"J Infect Chemother"},{"key":"2025082712310599000_18.6.e266152.10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/00494755221101777","article-title":"Hypervirulent Klebsiella pneumoniae infection presenting as endocarditis and liver abscess","volume":"52","author":"Hamide","year":"2022","journal-title":"Trop Doct"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T19:31:12Z","timestamp":1756323072000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,27]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/bcr-2025-266152"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266152","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}