{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:27:15Z","timestamp":1783578435112,"version":"3.55.0"},"reference-count":9,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,5]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare medication adverse event that can lead to severe respiratory distress and clinical decompensation. Herein, we report a man in his 70s who was being treated with outpatient intravenous daptomycin for foot osteomyelitis and presented with fevers and shortness of breath. His clinical exam and imaging favoured an infectious pneumonia. However, the patient\u2019s respiratory and clinical status continued to decline despite broad-spectrum antibiotics. A diagnosis of DIEP was established by elevated peripheral eosinophil count and &gt;25% eosinophils on bronchoalveolar lavage. The patient\u2019s clinical status improved after discontinuing daptomycin and initiating systemic corticosteroid therapy.<\/jats:p>","DOI":"10.1136\/bcr-2025-266295","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T10:00:23Z","timestamp":1752832823000},"page":"e266295","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Daptomycin and acute lung injury: recognising drug-induced eosinophilic pneumonia"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-5186","authenticated-orcid":false,"given":"Lynn Marie","family":"Utley","sequence":"first","affiliation":[{"name":"Family Medicine, Kaiser Permanente Woodland Hills, Woodland Hills, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Larsen","sequence":"additional","affiliation":[{"name":"Family Medicine, Kaiser Permanente Woodland Hills, Woodland Hills, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Family Medicine, Kaiser Permanente Woodland Hills, Woodland Hills, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Barjasteh","sequence":"additional","affiliation":[{"name":"Family Medicine, Kaiser Permanente Woodland Hills, Woodland Hills, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"2025082700575629000_18.7.e266295.1","doi-asserted-by":"publisher","DOI":"10.2165\/11597460-000000000-00000"},{"key":"2025082700575629000_18.7.e266295.2","article-title":"Daptomycin-Induced Acute Eosinophilic Pneumonia: Late Onset and Quick Recovery","volume":"2017","author":"Rachid","year":"2017","journal-title":"Case Rep Pulmonol"},{"key":"2025082700575629000_18.7.e266295.3","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000009688","article-title":"Drug-induced eosinophilic pneumonia: A review of 196 case reports","volume":"97","author":"Bartal","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2025082700575629000_18.7.e266295.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2006.11.006"},{"key":"2025082700575629000_18.7.e266295.5","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s15010-024-02349-z","article-title":"Daptomycin eosinophilic pneumonia, a systematic review of the literature and case series","volume":"52","author":"Gidari","year":"2024","journal-title":"Infection"},{"key":"2025082700575629000_18.7.e266295.6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jiac.2016.09.001","article-title":"Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions and a review of the literature","volume":"23","author":"Hirai","year":"2017","journal-title":"J Infect Chemother"},{"key":"2025082700575629000_18.7.e266295.7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2169\/internalmedicine.9010-17","article-title":"Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature","volume":"57","author":"Higashi","year":"2018","journal-title":"Intern Med"},{"key":"2025082700575629000_18.7.e266295.8","article-title":"Daptomycin-Induced Pulmonary Toxicity: A Case Series","volume":"15","author":"Patel","year":"2023","journal-title":"Cureus"},{"key":"2025082700575629000_18.7.e266295.9","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofac065","article-title":"Eosinophilic Syndromes Associated With Daptomycin Use: Re-exposure Hypersensitivity Pneumonitis and Prior Peripheral Eosinophilia","volume":"9","author":"West","year":"2022","journal-title":"Open Forum Infect Dis"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:58:03Z","timestamp":1756281483000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":9,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,18]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bcr-2025-266295"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266295","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}