{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T21:09:06Z","timestamp":1784408946703,"version":"3.55.0"},"reference-count":18,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,6]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>A middle-aged man with metastatic lung adenocarcinoma presented with acute dyspnoea and chest tightness, triggering a primary percutaneous coronary intervention alert for suspected myocardial infarction. He had a left-sided deep vein thrombosis diagnosed 1\u2009week prior, treated with rivaroxaban and was on day 3 of entrectinib chemotherapy for lung cancer. Examination revealed haemodynamic compromise. Electrocardiography revealed widespread ST elevation (V2\u2013V6, II, III, aVF), but coronary angiography showed unobstructed coronary arteries. Echocardiography and elevated troponin levels suggested right ventricular strain, prompting CT pulmonary angiography, which confirmed pulmonary embolism. He required intensive care unit admission, oxygen supplementation and vasopressors. Subsequently, he developed sustained ventricular tachycardia, managed with an amiodarone infusion. Rivaroxaban was switched to intravenous unfractionated heparin. This case highlights pulmonary embolism (PE) occurring despite therapeutic anticoagulation, suggesting direct oral anticoagulant failure, possibly due to entrectinib reducing rivaroxaban bioavailability. It also demonstrates PE mimicking ST-elevation myocardial infarction and VT in a high-risk patient.<\/jats:p>","DOI":"10.1136\/bcr-2025-266296","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T14:25:26Z","timestamp":1750775126000},"page":"e266296","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Pulmonary embolism masquerading as ST elevation myocardial infarction and ventricular tachycardia"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-6598","authenticated-orcid":false,"given":"May Honey","family":"Ohn","sequence":"first","affiliation":[{"name":"Cardiology Department, King\u2019s College Hospital NHS Foundation Trust, London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"2025082804325666000_18.6.e266296.1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.809"},{"key":"2025082804325666000_18.6.e266296.2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/anec.12278","article-title":"The value of electrocardiographic abnormalities in the prognosis of pulmonary embolism: a consensus paper","volume":"20","author":"Digby","year":"2015","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2025082804325666000_18.6.e266296.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-4679(01)00381-X"},{"key":"2025082804325666000_18.6.e266296.4","first-page":"662","article-title":"Massive Pulmonary Embolism With ST Elevation in Leads V1-V3 and Successful Aspiration Thrombectomy: Case Report and Review of EKG Changes in Acute Pulmonary Embolism","volume":"4","author":"Mohammad","year":"2013","journal-title":"J Med Cases"},{"key":"2025082804325666000_18.6.e266296.5","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32834102ea"},{"key":"2025082804325666000_18.6.e266296.6","first-page":"660","article-title":"Pulmonary Embolism Presenting as an Anterior ST-elevation Myocardial Infarction: A Case Report","volume":"4","author":"Ladage","year":"2020","journal-title":"Clin Pract Cases Emerg Med"},{"key":"2025082804325666000_18.6.e266296.7","first-page":"344","article-title":"Pulmonary embolism mimicking anteroseptal acute myocardial infarction","volume":"108","author":"Wilson","year":"2008","journal-title":"J Am Osteopath Assoc"},{"key":"2025082804325666000_18.6.e266296.8","doi-asserted-by":"crossref","unstructured":"Mistry A , Natarajan N , Hussain S , et al . Unusual presentation of acute pulmonary embolus presenting with inferior ST elevation. 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