{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:59:32Z","timestamp":1757609972571,"version":"3.44.0"},"reference-count":8,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,8,15]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Uveitis is a significant cause of visual impairment and is often linked to underlying systemic immune-mediated conditions. Retroperitoneal fibrosis, characterised by the proliferation of fibrotic tissue in the retroperitoneum, can similarly be associated with autoimmune or autoinflammatory diseases. While both conditions have been reported in the context of systemic disorders, their co-occurrence in the absence of a defined systemic diagnosis is exceedingly rare, with only two such cases previously documented.<\/jats:p>\n               <jats:p>We report the case of a woman in her 30s with a history of idiopathic retroperitoneal fibrosis who later developed recurrent bilateral uveitis. Extensive investigations failed to identify an underlying associated disorder. While a direct aetiological link between the two conditions remains unproven, their coexistence raises the possibility of a shared immune-mediated mechanism. The patient responded favourably to corticosteroids and anti-TNF therapy, further supporting an immune-mediated pathogenesis.<\/jats:p>","DOI":"10.1136\/bcr-2025-266311","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:35:19Z","timestamp":1756902919000},"page":"e266311","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Uveitis and idiopathic retroperitoneal fibrosis: an unusual association"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7698-4599","authenticated-orcid":false,"given":"Marta","family":"Salas S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Community of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabela","family":"Casta\u00f1eda P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Community of Galicia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Ibares Fr\u00edas","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Community of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Lavilla Olleros","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Community of Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Madrid, Community of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"2025090305350956000_18.9.e266311.1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.m4979","article-title":"Uveitis for the non-ophthalmologist","volume":"372","author":"Burkholder","year":"2021","journal-title":"BMJ"},{"key":"2025090305350956000_18.9.e266311.2","doi-asserted-by":"crossref","first-page":"18560683","DOI":"10.4321\/S0212-71992008000300009","article-title":"Uve\u00edtis: Un reto para el internista","volume":"25","author":"Calvo Hern\u00e1ndez","year":"2008","journal-title":"An Med Interna (Madrid)"},{"key":"2025090305350956000_18.9.e266311.3","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-018-1522-2","article-title":"Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013","volume":"20","author":"Oh","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"2025090305350956000_18.9.e266311.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68035-5"},{"key":"2025090305350956000_18.9.e266311.5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.04.019"},{"key":"2025090305350956000_18.9.e266311.6","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/ICU.0000000000000427","article-title":"IgG4-related disease in the eye and ocular adnexa","volume":"28","author":"Derzko-Dzulynsky","year":"2017","journal-title":"Curr Opin Ophthalmol"},{"key":"2025090305350956000_18.9.e266311.7","doi-asserted-by":"crossref","unstructured":"Alpert DR , Patel J , Chiang PK . Idiopathic retroperitoneal fibrosis presenting with recurrent bilateral uveitis. BMJ Case Rep 2011;2011. doi:10.1136\/bcr.08.2011.4701","DOI":"10.1136\/bcr.08.2011.4701"},{"key":"2025090305350956000_18.9.e266311.8","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0002-9394(14)73146-0","article-title":"A case of uveitis associated with idiopathic retroperitoneal fibrosis","volume":"117","author":"Doi","year":"1994","journal-title":"Am J Ophthalmol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:35:21Z","timestamp":1756902921000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":8,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,3]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1136\/bcr-2025-266311"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266311","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}