{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T21:55:43Z","timestamp":1757627743351,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,8,21]]},"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>Fahr\u2019s syndrome is a rare neurological condition marked by unusual calcifications in the basal ganglia and other brain regions, often resulting from metabolic disorders, such as hypoparathyroidism. Secondary hypoparathyroidism, a frequent complication of total thyroidectomy, can lead to Fahr\u2019s syndrome, manifesting as movement disorders, seizures, psychiatric symptoms and indications of calcium deficiency. This case report discusses a woman in her mid-30s who developed Fahr\u2019s syndrome due to secondary hypoparathyroidism after total thyroidectomy. She exhibited signs of calcium deficiency and had a history of seizures diagnosed a few years postsurgery, without any movement disorders or psychiatric symptoms. Her lab results showed low calcium levels, elevated phosphate and high thyroid-stimulating hormone levels. Imaging revealed bilateral calcifications in the basal ganglia, dentate nucleus and cerebral hemispheres. Treatment with intravenous calcium gluconate, calcitriol and thyroxine significantly improved the patient\u2019s symptoms. This case underscores the necessity of monitoring calcium and phosphate levels in patients after thyroidectomy and highlights the possibility of Fahr\u2019s syndrome presenting solely with seizures. The early detection and diagnosis of this condition are crucial for preventing further neurological damage and enhancing patient outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2025-266319","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T04:40:26Z","timestamp":1757479226000},"page":"e266319","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Seizures and hypoparathyroidism post-thyroidectomy: Fahr\u2019s syndrome"],"prefix":"10.1136","volume":"18","author":[{"given":"Shruti Manoj","family":"Mundada","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Gandhi Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5626-3748","authenticated-orcid":false,"given":"Tanvi Reddy","family":"Sanivarapu","sequence":"additional","affiliation":[{"name":"Osmania Medical College, Hyderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2693-3996","authenticated-orcid":false,"given":"Suhas","family":"Kataveni","sequence":"additional","affiliation":[{"name":"Gandhi Medical College and Hospital, Secunderabad, Telangana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"2025090921401935000_18.9.e266319.1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-156"},{"key":"2025090921401935000_18.9.e266319.2","article-title":"Young Male With Seizure Disorder and Intracranial Calcification: A Case of Fahr\u2019s Syndrome","volume":"14","author":"G","year":"2022","journal-title":"Cureus"},{"key":"2025090921401935000_18.9.e266319.3","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-242837","article-title":"Fahr\u2019s disease with an initial presentation of crescendo TIA","volume":"14","author":"Smith","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2025090921401935000_18.9.e266319.4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4183\/aeb.2020.370","article-title":"Epileptic Seizures as te First Manifestation of Fahr\u2019s Syndrome","volume":"16","author":"Manea","year":"2020","journal-title":"Acta Endo (Buc)"},{"key":"2025090921401935000_18.9.e266319.5","doi-asserted-by":"crossref","DOI":"10.1177\/11795476231178119","article-title":"Fahr\u2019s Syndrome Secondary to Primary Hypoparathyroidism Presenting With Seizures and the Role of Steroid Therapy","volume":"16","author":"Shah","year":"2023","journal-title":"Clin Med Insights Case Rep"},{"key":"2025090921401935000_18.9.e266319.6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s40618-020-01355-w","article-title":"Basal ganglia calcification in hypoparathyroidism and pseudohypoparathyroidism: local and systemic metabolic mechanisms","volume":"44","author":"Zavatta","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"2025090921401935000_18.9.e266319.7","article-title":"Risk Factors for Transient and Permanent Hypoparathyroidism Following Thyroidectomy: A Comprehensive Review","volume":"16","author":"Maheshwari","year":"2024","journal-title":"Cureus"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T04:40:27Z","timestamp":1757479227000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":7,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9,9]]},"published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1136\/bcr-2025-266319"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266319","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]}}}