{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T18:10:14Z","timestamp":1756318214526,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,6,14]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Hypo-hyperdontia, the simultaneous occurrence of hypodontia and hyperdontia, is a rare dental anomaly, especially in the mandibular anterior region. This case report presents a male patient with unilateral agenesis of the mandibular central incisor (41) and the presence of mesiodens. Clinical and radiographic evaluation confirmed the diagnosis. Due to its potential impact on occlusion, function and aesthetics, a conservative approach was adopted, retaining the mesiodens to preserve arch integrity and support craniofacial development. The case highlights the importance of early diagnosis, thorough radiographic assessment and individualised treatment planning in managing hypo-hyperdontia. Follow-up is ongoing to monitor long-term stability and functional outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2025-266439","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T14:05:33Z","timestamp":1750860333000},"page":"e266439","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mandibular anterior hypo-hyperdontia: a rare mixed dentition anomaly"],"prefix":"10.1136","volume":"18","author":[{"given":"Ayisha","family":"Beevi","sequence":"first","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George\u2019s Medical University Faculty of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3841-0676","authenticated-orcid":false,"given":"Abhilasha","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George\u2019s Medical University Faculty of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajeev Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George\u2019s Medical University Faculty of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1397-8448","authenticated-orcid":false,"given":"Devshri","family":"Vaja","sequence":"additional","affiliation":[{"name":"Department of Paediatric and Preventive Dentistry, King George\u2019s Medical University Faculty of Dental Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"2025082710385580000_18.6.e266439.1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.66"},{"key":"2025082710385580000_18.6.e266439.2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517720158"},{"key":"2025082710385580000_18.6.e266439.3","first-page":"338","article-title":"Concomitant hypodontia and hyperodontia. Case report","volume":"123","author":"Camilleri","year":"1967","journal-title":"Br Dent J"},{"key":"2025082710385580000_18.6.e266439.4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1179\/bjo.6.2.101","article-title":"Concomitant hypo-hyperodontia","volume":"6","author":"Gibson","year":"1979","journal-title":"Br J Orthod"},{"key":"2025082710385580000_18.6.e266439.5","first-page":"309","article-title":"Letter to the editor","volume":"129","author":"Nathanail","year":"1970","journal-title":"Br Dent J"},{"key":"2025082710385580000_18.6.e266439.6","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/j.tripleo.2008.07.012","article-title":"Hypohyperdontia: literature review and report of seven cases","volume":"106","author":"Anthonappa","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol"},{"key":"2025082710385580000_18.6.e266439.7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2334\/josnusd.56.295","article-title":"A comprehensive review of the literature and data analysis on hypo-hyperdontia","volume":"56","author":"Mallineni","year":"2014","journal-title":"J Oral Sci"},{"key":"2025082710385580000_18.6.e266439.8","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/2231-0762.122451","article-title":"Mandibular hypo-hyperdontia: A report of three cases","volume":"3","author":"Nirmala","year":"2013","journal-title":"J Int Soc Prev Community Dent"},{"key":"2025082710385580000_18.6.e266439.9","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jds.2018.01.001","article-title":"Concomitant hypo-hyperdontia: A rare entity","volume":"13","author":"Wang","year":"2018","journal-title":"J Dent Sci"},{"key":"2025082710385580000_18.6.e266439.10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.17796\/1053-4628-39.4.371","article-title":"Birth-Weight, Pregnancy Term, Pre-Natal and Natal Complications Related to Child\u2019s Dental Anomalies","volume":"39","author":"Prokocimer","year":"2015","journal-title":"J Clin Pediatr Dent"},{"key":"2025082710385580000_18.6.e266439.11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cden.2016.02.005","article-title":"The Special Needs of Preterm Children - An Oral Health Perspective","volume":"60","author":"Tsang","year":"2016","journal-title":"Dent Clin North Am"},{"key":"2025082710385580000_18.6.e266439.12","first-page":"159","article-title":"Oral manifestations of Ellis-van Creveld syndrome: report of two siblings with unusual dental anomalies","volume":"22","author":"Hattab","year":"1998","journal-title":"J Clin Pediatr Dent"},{"key":"2025082710385580000_18.6.e266439.13","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.4103\/0970-4388.43538","article-title":"A rare case of concomitant hypo-hyperdontia in identical twins","volume":"26 Suppl 2","author":"Sharma","year":"2008","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"2025082710385580000_18.6.e266439.14","doi-asserted-by":"crossref","unstructured":"Mallineni SK . Supernumerary teeth: review of the literature with recent updates. In: Conference papers in science 2014 (vol. 2014, No. 1, p. 764050). Hindawi Publishing Corporation, 2014: 1\u20136.","DOI":"10.1155\/2014\/764050"},{"key":"2025082710385580000_18.6.e266439.15","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.jds.2021.12.009","article-title":"Relationship between craniofacial morphology and congenitally missing mandibular incisors","volume":"17","author":"Chen","year":"2022","journal-title":"J Dent Sci"},{"key":"2025082710385580000_18.6.e266439.16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1179\/bjo.4.4.187","article-title":"Hypodontia and supernumerary tooth: report of a case and its management","volume":"4","author":"Low","year":"1977","journal-title":"Br J Orthod"},{"key":"2025082710385580000_18.6.e266439.17","first-page":"S33","article-title":"Coexistent partial anodontia and supernumerary tooth in the mandibular arch: a rare case","volume":"24 Suppl 1","author":"Das","year":"2006","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"2025082710385580000_18.6.e266439.18","doi-asserted-by":"crossref","unstructured":"Raghavan VH . Mandibular meslodens with agenesis of central incisors - A rare association. Niger Dent J 2009;17. doi:10.4314\/ndj.v17i1.54387","DOI":"10.4314\/ndj.v17i1.54387"},{"key":"2025082710385580000_18.6.e266439.19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/0976-237X.72775","article-title":"Hypohyperdontia: Agenesis of three third molars and mandibular centrals associated with midline supernumerary tooth in mandible","volume":"1","author":"Nuvvula","year":"2010","journal-title":"Contemp Clin Dent"},{"key":"2025082710385580000_18.6.e266439.20","unstructured":"Nayak AG , Chhaparwal Y , Pai KM , et al . Non-syndromic hypohyperdontia of the permanent dentition with involvement of the mandibular anterior region: a rare occurrence. Arch Oral Res 2010;6."},{"key":"2025082710385580000_18.6.e266439.21","unstructured":"Venkataraghavan K , Muralikrishnan B , Anantharaj A . Mandibular Mesiodens with Agenesis of Central Incisors (Hypohyperdontia): A Case Report &Review. Int J Contemp Dent 2011;2."},{"key":"2025082710385580000_18.6.e266439.22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF03262841","article-title":"Case report: a rare occurrence of non-syndromic hypo-hyperdontia in the mandibular anterior region","volume":"13","author":"Verma","year":"2012","journal-title":"Eur Arch Paediatr Dent"},{"key":"2025082710385580000_18.6.e266439.23","first-page":"65","article-title":"Mandibular midline supernumerary tooth associated with agenesis of permanent central incisors: a diagnostic conundrum","volume":"14","author":"Marya","year":"2012","journal-title":"Stomatologija"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:39:08Z","timestamp":1756316348000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6,25]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/bcr-2025-266439"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266439","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}