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She received 4 cycles of systemic chemotherapy, along with concurrent radiation therapy, followed by prophylactic cranial irradiation (PCI). Unfortunately, she developed two small metachronous brain metastases, 3 months and 12 months after PCI. Given no other disease activity on CT and subsequent positron emission tomography, she received stereotactic radiosurgery without systemic therapy. She remains in remission for &gt;3 years with no evidence of disease without any need for ongoing active systemic therapy.<\/jats:p>","DOI":"10.1136\/bcr-2025-266542","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T21:30:21Z","timestamp":1751405421000},"page":"e266542","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["An example of long-term remission in oligorecurrent relapsed small-cell lung cancer, following single modality radiation therapy"],"prefix":"10.1136","volume":"18","author":[{"given":"Natalie","family":"Shammas","sequence":"first","affiliation":[{"name":"Internal Medicine, CHI Saint Vincent Health System, Little Rock, Arkansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajjad","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Hematology and Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"2025082803192072000_18.7.e266542.1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5306\/wjco.v13.i6.429","article-title":"New perspectives in the management of small cell lung cancer","volume":"13","author":"Pangua","year":"2022","journal-title":"World J Clin Oncol"},{"key":"2025082803192072000_18.7.e266542.2","unstructured":"National Cancer Institute . 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Available: https:\/\/www.nccn.org\/guidelines\/category_1"},{"key":"2025082803192072000_18.7.e266542.5","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2024.42.17_suppl.LBA5","article-title":"ADRIATIC: Durvalumab (D) as consolidation treatment (tx) for patients (pts) with limited-stage small-cell lung cancer (LS-SCLC)","volume":"42","author":"Spigel","year":"2024","journal-title":"JCO"},{"key":"2025082803192072000_18.7.e266542.6","doi-asserted-by":"crossref","first-page":"166557","DOI":"10.1016\/j.bbadis.2022.166557","article-title":"Small-cell lung cancer brain metastasis: From molecular mechanisms to diagnosis and treatment","volume":"1868","author":"Zhu","year":"2022","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"2025082803192072000_18.7.e266542.7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.trecan.2020.04.007","article-title":"Genes that Mediate Metastasis across the Blood-Brain Barrier","volume":"6","author":"Fares","year":"2020","journal-title":"Trends Cancer"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:19:36Z","timestamp":1756376376000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":7,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,1]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bcr-2025-266542"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266542","relation":{},"ISSN":["1757-790X"],"issn-type":[{"type":"electronic","value":"1757-790X"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}