{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:43:11Z","timestamp":1756381391024,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,5,10]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome is a rare condition characterised by symmetrical swelling of the hands and\/or feet and pitting oedema. The symmetry of the symptoms, as indicated by the name, is a hallmark of RS3PE syndrome as well as most other forms of systemic, autoimmune disease. However, cases with only unilateral involvement of the non-paralytic side have reportedly been associated with various rheumatic disorders, particularly those involving hemiplegia. Clinical awareness of such conditions is poor. Herein, we describe a unique case of unilateral RS3PE syndrome in a patient with pre-existing hemiplegia. The findings of this report underscore the need for clinicians to recognise that RS3PE syndrome does not always present symmetrically in patients with a neurological deficit.<\/jats:p>","DOI":"10.1136\/bcr-2025-266546","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T09:25:36Z","timestamp":1747387536000},"page":"e266546","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral RS3PE syndrome in a patient with hemiplegia"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1210-2859","authenticated-orcid":false,"given":"Yasuhiro","family":"Kano","sequence":"first","affiliation":[{"name":"Department of Emergency and General Medicine, Tokyo Metropolitan Tama Medical Center, Fuchu, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kae","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of 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