{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:11:02Z","timestamp":1790010662799,"version":"4.0.1"},"reference-count":9,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,7,13]]},"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>A female in her 30s from Missouri with no significant past medical history presented to the emergency department with worsening fatigue, haematuria and back pain following a brown recluse spider bite. On admission, laboratory findings were significant for anaemia, leukocytosis, hyperbilirubinaemia, elevated lactate dehydrogenase, low haptoglobin and a positive direct antiglobulin test. The working diagnosis was autoimmune haemolytic anaemia secondary to a brown recluse spider bite; a rare but serious haematologic complication associated with brown recluse spider bites. The patient required multiple red blood cell transfusions, high-dose corticosteroids and antibiotic therapy. Her condition improved with pharmacologic treatment, and she was discharged home with outpatient haematology follow-up. This case highlights the potential for systemic haemolysis in the setting of brown recluse spider bites and underscores the importance of early recognition and comprehensive management.<\/jats:p>","DOI":"10.1136\/bcr-2025-266661","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T01:10:17Z","timestamp":1753665017000},"page":"e266661","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Autoimmune haemolytic anaemia secondary to a brown recluse spider bite"],"prefix":"10.1136","volume":"18","author":[{"given":"Shruti","family":"Rai","sequence":"first","affiliation":[{"name":"Ponce Health Sciences University - St Louis Campus, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Alan","family":"Hurth","sequence":"additional","affiliation":[{"name":"Internal Medicine, Mercy Hospital St Louis Area, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor Scott","family":"Shaw","sequence":"additional","affiliation":[{"name":"Mercy Hospital St Louis Area, St. Louis, Missouri, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"2025082801250056000_18.7.e266661.1","unstructured":"Anoka IA , Robb EL , Baker MB . 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A rare case of coombs-positive hemolytic anemia due to brown recluse spider bite. American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA; May 2020 doi:10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A1684 Available: https:\/\/www.atsjournals.org\/doi\/book\/10.1164\/ajrccm-conference.2020.A43","DOI":"10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A1684"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T08:25:12Z","timestamp":1756369512000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":9,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7,27]]},"published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1136\/bcr-2025-266661"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266661","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}