{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:18:05Z","timestamp":1780503485887,"version":"3.54.1"},"reference-count":10,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,4,22]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>Sterile infiltrates following collagen crosslinking (CXL) are an uncommon complication, typically reported in the early postoperative period. A patient in her mid-20s was diagnosed with keratoconus and underwent an uneventful CXL procedure. She demonstrated normal healing of the corneal epithelial defect postoperatively, and bandage contact lens was removed on postoperative day 4. The patient presented with peripheral corneal infiltrates on day 15 following surgery. The infiltrates were noted 1\u20132\u2009mm from the limbus at the 8\u201310 o\u2019clock position. Lid examination revealed mild Meibomian Gland Dysfunction (MGD) in both eyes. Autoimmune work up was unremarkable. A diagnosis of late-onset sterile keratitis was made, and topical steroids were intensified under antibiotic cover. The infiltrates resolved gradually over 3 weeks, leaving a residual scar. CXL may result in prolonged immune alterations in the cornea, rendering it more sensitive to antigenic stimuli.<\/jats:p>","DOI":"10.1136\/bcr-2025-266869","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:55:12Z","timestamp":1780502112000},"page":"e266869","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Late presentation of peripheral corneal infiltrates after collagen crosslinking in keratoconus"],"prefix":"10.1136","volume":"19","author":[{"given":"Pooja","family":"Jain","sequence":"first","affiliation":[{"name":"Cornea, Refractive & Cataract Surgery, Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashra","family":"Alma","sequence":"additional","affiliation":[{"name":"Cornea, Refractive & Cataract Surgery, Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roopashri","family":"Matada","sequence":"additional","affiliation":[{"name":"Cornea, Refractive & Cataract Surgery, Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay R","family":"Murthy","sequence":"additional","affiliation":[{"name":"Cornea, Refractive & Cataract Surgery, Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavya","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Cornea, Refractive & Cataract Surgery, Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,3]]},"reference":[{"key":"2026060308550692000_19.6.e266869.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)02220-1"},{"key":"2026060308550692000_19.6.e266869.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2009.03.035"},{"key":"2026060308550692000_19.6.e266869.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2008.11.050"},{"key":"2026060308550692000_19.6.e266869.4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/ICO.0b013e318226da53","article-title":"Peripheral sterile corneal ring infiltrate after riboflavin-UVA collagen cross-linking in keratoconus","volume":"31","author":"Ghanem","year":"2012","journal-title":"Cornea"},{"key":"2026060308550692000_19.6.e266869.5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/aos.13218","article-title":"Sterile corneal infiltrates after corneal collagen cross-linking: evaluation of risk factors","volume":"95","author":"\u00c7erman","year":"2017","journal-title":"Acta Ophthalmol"},{"key":"2026060308550692000_19.6.e266869.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2007.06.036"},{"key":"2026060308550692000_19.6.e266869.7","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e318240c7ff"},{"key":"2026060308550692000_19.6.e266869.8","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.12.7.12"},{"key":"2026060308550692000_19.6.e266869.9","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/jovr.jovr_100_18","article-title":"Recurrent peripheral stromal keratitis following corneal collagen cross-linking: A case report","volume":"14","author":"Faramarzi","year":"2019","journal-title":"J Ophthalmic Vis Res"},{"key":"2026060308550692000_19.6.e266869.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.05.042"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-266869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:55:13Z","timestamp":1780502113000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-266869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,3]]},"published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1136\/bcr-2025-266869"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-266869","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]}}}