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After exclusion of common causes of pancreatitis, a systemic inflammatory or vasculitic process was suspected. Treatment with intravenous methylprednisolone, followed by a tapering course of oral prednisone, led to clinical stabilisation. Given the clinical evolution and the patient\u2019s ethnic background, Beh\u00e7et\u2019s disease was strongly suspected, and therapy with colchicine, adalimumab and mycophenolate mofetil was initiated. The patient improved significantly and was discharged with plans for outpatient rheumatology follow-up. This case highlights a rare but serious gastrointestinal manifestation of Beh\u00e7et\u2019s disease and underscores the importance of early recognition and immunosuppressive management in systemic vasculitides.<\/jats:p>","DOI":"10.1136\/bcr-2025-267112","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T06:20:24Z","timestamp":1763101224000},"page":"e267112","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Acute necrotising pancreatitis in a patient with Beh\u00e7et\u2019s disease"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2317-6717","authenticated-orcid":false,"given":"Abdullah Anwar","family":"Albadi","sequence":"first","affiliation":[{"name":"Internal Medicine, Aljouf Health Cluster, Sakaka, Saudi 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