{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T02:06:19Z","timestamp":1763949979935,"version":"3.45.0"},"reference-count":11,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,11,7]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>We describe the case of a young woman with recurrent rhabdomyolysis caused by mixed connective tissue disease (MCTD). She initially presented with subacute progressive muscle weakness, myalgia, headache, fever, dark urine and diplopia. Examination revealed proximal muscle weakness, bilateral VI nerve palsies and mild periorbital oedema. Blood tests showed creatine kinase (CK) of 63\u2009770 IU\/L. Other investigations revealed aseptic meningitis, and pleural and pericardial effusions. Her anti-U1 ribonuclear protein antibody was positive. Detailed screening for other causes of rhabdomyolysis was negative, and muscle investigations (MRI and biopsy) were consistent with resolving rhabdomyolysis. She recovered fully, then experienced two further similar episodes in the following 9\u2009months. She has been diagnosed with MCTD presenting with recurrent rhabdomyolysis. To our knowledge, this phenomenon has not been reported in the literature.<\/jats:p>","DOI":"10.1136\/bcr-2025-267167","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T02:05:20Z","timestamp":1763949920000},"page":"e267167","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mixed connective tissue disease presenting with recurrent rhabdomyolysis"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3211-5676","authenticated-orcid":false,"given":"Louisa","family":"Kent","sequence":"first","affiliation":[{"name":"Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Butterworth","sequence":"additional","affiliation":[{"name":"Neurology, Milton Keynes University Hospital, Milton Keynes, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Hofer","sequence":"additional","affiliation":[{"name":"Neuropathology, Oxford University, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Giavri","sequence":"additional","affiliation":[{"name":"Rheumatology, Milton Keynes University Hospital, Milton Keynes, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefen","family":"Brady","sequence":"additional","affiliation":[{"name":"Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"2025112318051218000_18.11.e267167.1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13317-018-0105-1","article-title":"Rhabdomyolysis secondary to systemic lupus erythematosus","volume":"9","author":"Nguyen","year":"2018","journal-title":"Auto Immun Highlights"},{"key":"2025112318051218000_18.11.e267167.2","article-title":"Rhabdomyolysis-induced acute kidney injury in a patient with undifferentiated connective tissue disease","volume":"98","author":"Mai","year":"2019","journal-title":"Medicine (Abingdon)"},{"key":"2025112318051218000_18.11.e267167.3","doi-asserted-by":"publisher","DOI":"10.1186\/cc3221"},{"key":"2025112318051218000_18.11.e267167.4","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1001\/jamainternmed.2013.9774","article-title":"A risk prediction score for kidney failure or mortality in rhabdomyolysis","volume":"173","author":"McMahon","year":"2013","journal-title":"JAMA Intern Med"},{"key":"2025112318051218000_18.11.e267167.5","unstructured":"Sapkota B , Al Khalili Y . Mixed connective tissue disease. In: StatPearls. 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