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Histopathology met the criteria for malignancy. 2 years post-surgery, there was no recurrence. This case highlights the importance of recognising and treating malignant granular cell tumours, particularly in rare intramuscular and lower extremity presentations.<\/jats:p>","DOI":"10.1136\/bcr-2025-267188","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:00:25Z","timestamp":1756990825000},"page":"e267188","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Malignant granular cell tumour of the hamstring muscles"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-8527","authenticated-orcid":false,"given":"Anand","family":"Raja","sequence":"first","affiliation":[{"name":"Surgical Oncology, Cancer Institute WIA and Research Centre, Chennai, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishnu","family":"Ramanujan","sequence":"additional","affiliation":[{"name":"Orthopedic Oncology, Apollo Proton Cancer Centre, Chennai, Chennai, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Jethani","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra Kumar","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Surgical Oncology, Cancer Institute WIA and Research Centre, Chennai, Tamilnadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"2025100220401375000_18.9.e267188.1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02078314"},{"key":"2025100220401375000_18.9.e267188.2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0344-0338(98)80119-2","article-title":"Malignant granular cell tumor: report of a case and review of the literature","volume":"194","author":"Sonobe","year":"1998","journal-title":"Pathol Res Pract"},{"key":"2025100220401375000_18.9.e267188.3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870715)60:2<220::AID-CNCR2820600217>3.0.CO;2-V"},{"key":"2025100220401375000_18.9.e267188.4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/00000478-199807000-00001","article-title":"Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation","volume":"22","author":"Fanburg-Smith","year":"1998","journal-title":"Am J SurgPathol"},{"key":"2025100220401375000_18.9.e267188.5","first-page":"2403","article-title":"A case of malignant granular cell tumor arisen in the chest wall (in Japanese with English abstract)","volume":"66","author":"Kataoka","year":"2005","journal-title":"J JpnSurg Assoc"},{"key":"2025100220401375000_18.9.e267188.6","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930130405"},{"key":"2025100220401375000_18.9.e267188.7","doi-asserted-by":"publisher","DOI":"10.1007\/s002560050204"},{"key":"2025100220401375000_18.9.e267188.8","first-page":"206","article-title":"A case of atypical granular cell tumor in rectus abdominis muscle (in Japanese with English abstract)","volume":"67","author":"Natsume","year":"2006","journal-title":"J JpnSurg Assoc"},{"key":"2025100220401375000_18.9.e267188.9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2008.01100.x"},{"key":"2025100220401375000_18.9.e267188.10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.annder.2017.06.008","article-title":"Multiple granular cell tumours in a patient with Noonan\u2019s syndrome and juvenile myelomonocytic leukaemia","volume":"144","author":"Castagna","year":"2017","journal-title":"Ann Dermatol Venereol"},{"key":"2025100220401375000_18.9.e267188.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05886-y"},{"key":"2025100220401375000_18.9.e267188.12","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/PAS.0000000000001122","article-title":"Cutaneous Non-Neural Granular Cell Tumors Harbor Recurrent ALK Gene Fusions","volume":"42","author":"Cohen","year":"2018","journal-title":"Am J Surg Pathol"},{"key":"2025100220401375000_18.9.e267188.13","first-page":"1384","article-title":"Intramuscular Granular Cell Tumor in the Lower Extremities","volume":"468","author":"Arai","year":"2010","journal-title":"ClinOrthopRelat Res"},{"key":"2025100220401375000_18.9.e267188.14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00003086-200011000-00026","article-title":"Granular Cell Tumors of the Extremities","volume":"380","author":"Elkousy","year":"2000","journal-title":"Clin Orthop Relat Res"},{"key":"2025100220401375000_18.9.e267188.15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/01.blo.0000238786.06231.17","article-title":"Case report. 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