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This has implications from both a speculative and a clinical point of view. Indeed, we do not consider it sufficient to define FPIES as a non-IgE-mediated FA. There are numerous indications that suggest a role for IgE in at least some patients. Therefore, we would prefer it to be classified as a mixed form. Some patients, such as the one described in our paper, are definable as \u2018in the middle of the ford\u2019. From a clinical point of view, the identification of a role for specific IgE could hypothetically facilitate the choice of certain dietary indications, such as testing tolerance to processed cow\u2019s milk derivatives.<\/jats:p>","DOI":"10.1136\/bcr-2025-267332","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T18:05:14Z","timestamp":1767117914000},"page":"e267332","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Food protein-induced enterocolitis syndrome: a food allergy in the middle of the ford"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-6146","authenticated-orcid":false,"given":"Stefano","family":"Miceli Sopo","sequence":"first","affiliation":[{"name":"Pediatrics, Policlinico Universitario Agostino Gemelli Dipartimento Scienze della Salute della Donna e del Bambino, Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0325-2879","authenticated-orcid":false,"given":"Matteo","family":"Di Toro Mammarella","sequence":"additional","affiliation":[{"name":"Policlinico Universitario Agostino Gemelli Dipartimento Scienze della Salute della Donna e del Bambino, Rome, Lazio, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-1312","authenticated-orcid":false,"given":"Francesco","family":"Mastellone","sequence":"additional","affiliation":[{"name":"Policlinico Universitario Agostino Gemelli Dipartimento Scienze della Salute della Donna e del Bambino, Rome, Lazio, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Bersani","sequence":"additional","affiliation":[{"name":"Policlinico Universitario Agostino Gemelli Dipartimento Scienze della Salute della Donna e del Bambino, Rome, Lazio, 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