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Treatment of the underlying myopathy permitted significant recovery and return to ambulation, but with persistent very low bone density. To try to regain the lost bone mass, she was started on romosozumab. After 1 year of treatment, repeated measurements of bone mineral density showed an increase of 6% in her lumbar spine and 11% in her hip, respectively. Romosozumab use showed a significant recovery of nearly half of her original bone loss after her initial treatment with bisphosphonates.<\/jats:p>","DOI":"10.1136\/bcr-2025-267469","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T04:25:22Z","timestamp":1759119922000},"page":"e267469","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Recovery from immobilisation-associated osteoporosis with anti-resorptive and anabolic therapy"],"prefix":"10.1136","volume":"18","author":[{"given":"Maryell","family":"Urroz Lopez","sequence":"first","affiliation":[{"name":"University of Alberta Faculty of Medicine and Dentistry, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Kline","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,9,28]]},"reference":[{"key":"2025092821251649000_18.9.e267469.1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s00223-021-00836-1","article-title":"Disuse Osteoporosis: Clinical and Mechanistic Insights","volume":"110","author":"Rolvien","year":"2022","journal-title":"Calcif Tissue Int"},{"key":"2025092821251649000_18.9.e267469.2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02207242","article-title":"Immobilization osteoporosis: a review","volume":"8 Suppl 2","author":"Minaire","year":"1989","journal-title":"Clin Rheumatol"},{"key":"2025092821251649000_18.9.e267469.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.10.007"},{"key":"2025092821251649000_18.9.e267469.4","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-021-01016-8","article-title":"Bone Health in Idiopathic Inflammatory Myopathies: Diagnosis and Management","volume":"23","author":"Vincze","year":"2021","journal-title":"Curr Rheumatol Rep"},{"key":"2025092821251649000_18.9.e267469.5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3803\/EnM.2023.1673","article-title":"New Insights into Calorie Restriction Induced Bone Loss","volume":"38","author":"Liu","year":"2023","journal-title":"Endocrinol Metab"},{"key":"2025092821251649000_18.9.e267469.6","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.221647"},{"key":"2025092821251649000_18.9.e267469.7","doi-asserted-by":"publisher","DOI":"10.4158\/GL-2020-0524SUPPL"},{"key":"2025092821251649000_18.9.e267469.8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/jbmr.3735","article-title":"Bone-Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment","volume":"34","author":"Chavassieux","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2025092821251649000_18.9.e267469.9","unstructured":"National Institute for Health and Care Excellence (NICE) . 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