{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:05:53Z","timestamp":1756339553259,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,8,15]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Orbital metastasis is a rare manifestation of systemic malignancy, accounting for approximately 2%\u20135% of orbital tumours. The most common primary cancers associated with orbital metastases include breast carcinoma, malignant melanoma and prostate carcinoma. Hepatocellular carcinoma (HCC) is an uncommon source of all reported orbital metastases. We report the case of a man in his mid-50s with a history of alcoholic cirrhosis who presented with an acute onset of left periorbital pain, conjunctival injection, proptosis and restrictive ophthalmoplegia, in addition to abdominal discomfort. Orbital CT demonstrated a heterogeneously enhancing mass in the superolateral left orbit, associated with osseous erosion and displacement of adjacent orbital structures. Further imaging revealed multifocal hepatic lesions with evidence of portal vein invasion. A biopsy of the orbital mass confirmed metastatic HCC. The patient experienced rapid clinical deterioration before initiating treatment and ultimately passed away. This case highlights the importance of considering metastatic liver malignancy in the differential diagnosis of orbital masses, particularly in patients with risk factors for HCC.<\/jats:p>","DOI":"10.1136\/bcr-2025-267526","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T17:15:31Z","timestamp":1756314931000},"page":"e267526","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Unilateral restrictive ophthalmoplegia as the first manifestation of advanced hepatocellular carcinoma: orbital metastasis"],"prefix":"10.1136","volume":"18","author":[{"given":"Morgan","family":"Ogwo","sequence":"first","affiliation":[{"name":"Texas Tech University Health Sciences Centre El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lovasz","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Centre El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Kan","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Centre El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-9295","authenticated-orcid":false,"given":"Zhuo","family":"Luan","sequence":"additional","affiliation":[{"name":"Texas Tech University Health Sciences Centre El Paso Paul L Foster School of Medicine, El Paso, Texas, USA"},{"name":"Neurology, Texas Tech University Health Sciences Centre El Paso, El Paso, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"key":"2025082710152221000_18.8.e267526.1","doi-asserted-by":"crossref","unstructured":"Palmisciano P , Ferini G , Ogasawara C , et al . 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