{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:20:15Z","timestamp":1767190815771,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,12,12]]},"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Syphilis, known for its varied presentations, often mimics other conditions, posing diagnostic challenges. Secondary syphilis can rarely manifest as generalised lymphadenopathy, resembling lymphoproliferative disorders. A male in his late 20s presented with appetite loss, bilateral painless lymphadenopathy and hepatosplenomegaly. Initial investigations suggested a lymphoproliferative disorder. Biopsy revealed dermatopathic lymphadenopathy. Detailed sexual history confirmed syphilis, treated with benzathine penicillin, resolving symptoms and lymphadenopathy. Diagnostic delay occurred due to an incomplete sexual history. Syphilis should be considered, even without typical cutaneous manifestations. Similar cases highlight syphilis\u2019s resemblance to malignant lymphoma. Comprehensive patient education and a multidisciplinary approach are vital. Early diagnosis and treatment are essential for optimal outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2025-267799","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:35:22Z","timestamp":1767180922000},"page":"e267799","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Luetic lymphadenitis: solving the secretive swell"],"prefix":"10.1136","volume":"18","author":[{"given":"Preksha","family":"Luthra","sequence":"first","affiliation":[{"name":"Dermatology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2182-4801","authenticated-orcid":false,"given":"Kiran Sandeep","family":"Patil","sequence":"additional","affiliation":[{"name":"Dermatology, Krishna Institute of Medical Sciences (Deemed To Be University), Karad, Maharashtra, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Hussain","sequence":"additional","affiliation":[{"name":"Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, MH, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-9165","authenticated-orcid":false,"given":"Bhushan","family":"Madke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education & Research, Wardha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"2025123106150840000_18.12.e267799.1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jiac.2017.03.003","article-title":"Secondary syphilis mimicking malignancy: A case report and review of literature","volume":"23","author":"Cerchione","year":"2017","journal-title":"J Infect Chemother"},{"key":"2025123106150840000_18.12.e267799.2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/1874279301004010143","article-title":"Syphilis: A Review of the Diagnosis and Treatment","volume":"3","author":"Emerson","year":"2009","journal-title":"TOIDJ"},{"key":"2025123106150840000_18.12.e267799.3","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-4-406"},{"key":"2025123106150840000_18.12.e267799.4","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.radcr.2022.10.045","article-title":"Primary syphilis presenting as a painful unilateral inguinal lymphadenopathy, without cutaneous manifestations, in a 71-year-old Japanese man: A case report","volume":"18","author":"Yorita","year":"2023","journal-title":"Radiol Case Rep"},{"key":"2025123106150840000_18.12.e267799.5","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198010000-00002"},{"key":"2025123106150840000_18.12.e267799.6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0190-9622(80)80229-5","article-title":"Secondary syphilis mimicking mycosis fungoides","volume":"3","author":"Levin","year":"1980","journal-title":"J Am Acad Dermatol"},{"key":"2025123106150840000_18.12.e267799.7","doi-asserted-by":"crossref","unstructured":"Miranda RN , Khoury JD , Medeiros LJ . 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