{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T06:28:10Z","timestamp":1768631290734,"version":"3.49.0"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,1,6]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Brodie\u2019s abscess is a subacute form of osteomyelitis typically seen in the metaphysis of long bones. Its occurrence in the sacrum is extremely rare. We report a case of Brodie\u2019s abscess involving the S2 vertebra in a male in his early 30s with hereditary spherocytosis, who presented with chronic low back pain without systemic signs of infection. Imaging revealed a well-defined, sclerotic lesion in S2 suggestive of chronic osteomyelitis. A minimally invasive biopsy and curettage was performed. Intraoperative findings suggested early infection, though cultures were negative. Histopathology showed trabecular bone with marrow spaces containing either haematopoietic cells or fibrous tissue, indicating healing. The patient received targeted antibiotic irrigation and a short oral antibiotic course. At 1-year follow-up, he was asymptomatic with complete radiological resolution. This case of isolated sacral Brodie\u2019s abscess highlights the importance of early imaging and clinical suspicion in atypical spinal infections, especially in patients with haematological disorders that may obscure typical signs.<\/jats:p>","DOI":"10.1136\/bcr-2025-267832","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T19:00:40Z","timestamp":1768590040000},"page":"e267832","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sacral Brodie\u2019s abscess in a patient with hereditary spherocytosis"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-0111","authenticated-orcid":false,"given":"Saran","family":"J S R G","sequence":"first","affiliation":[{"name":"Orthopaedics, MS Ramaiah Medical College, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-858X","authenticated-orcid":false,"given":"Ravikumar","family":"Thoppanahalli Venkatesh","sequence":"additional","affiliation":[{"name":"Orthopaedics, MS Ramaiah Medical College, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapnika","family":"D","sequence":"additional","affiliation":[{"name":"Orthopaedics, MS Ramaiah University of Applied Sciences, Bengaluru, KA, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhay","family":"N","sequence":"additional","affiliation":[{"name":"Orthopaedics, MS Ramaiah University of Applied Sciences, Bengaluru, KA, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"2026011611001520000_19.1.e267832.1","doi-asserted-by":"crossref","first-page":"E102","DOI":"10.1097\/BSD.0000000000000597","article-title":"The Epidemiology of Vertebral Osteomyelitis in the United States From 1998 to 2013","volume":"31","author":"Issa","year":"2018","journal-title":"Clin Spine Surg"},{"key":"2026011611001520000_19.1.e267832.2","first-page":"00788","article-title":"Incidence and risk factors for native vertebral osteomyelitis: a retrospective cohort study using a National Claims Database","volume":"9","author":"Channer","year":"2025","journal-title":"Spine J"},{"key":"2026011611001520000_19.1.e267832.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0910753"},{"key":"2026011611001520000_19.1.e267832.4","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1093\/cid\/ciad377","article-title":"Risk Factors and Outcomes of Hematogenous Vertebral Osteomyelitis in Patients With Staphylococcus aureus Bacteremia","volume":"77","author":"Kinamon","year":"2023","journal-title":"Clin Infect Dis"},{"key":"2026011611001520000_19.1.e267832.5","doi-asserted-by":"crossref","DOI":"10.14444\/2042","article-title":"A Review of Symptomatic Lumbosacral Transitional Vertebrae: Bertolotti\u2019s Syndrome","volume":"9","author":"Jancuska","year":"2015","journal-title":"Int J Spine Surg"},{"key":"2026011611001520000_19.1.e267832.6","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200012000-00002"},{"key":"2026011611001520000_19.1.e267832.7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s13018-024-04799-5","article-title":"Vertebral hemangiomas: a review on diagnosis and management","volume":"19","author":"Kato","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"2026011611001520000_19.1.e267832.8","article-title":"Imaging of spinal metastatic disease","volume":"2011","author":"Shah","year":"2011","journal-title":"Int J Surg Oncol"},{"key":"2026011611001520000_19.1.e267832.9","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.7222"},{"key":"2026011611001520000_19.1.e267832.10","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.39640"},{"key":"2026011611001520000_19.1.e267832.11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.25259\/IJMSR_39_2021","article-title":"Imaging features in extramedullary hematopoiesis - 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