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The stenoses of two mesenteric vessels limited perfusion during periods of high metabolic demand, causing postprandial tissue ischaemia, which manifested as abdominal pain, reduced oral intake and consequent weight loss. A multidisciplinary approach led to the diagnosis of CMI and surgical revascularisation via iliomesenteric bypass was performed, resulting in complete resolution of symptoms and weight recovery. This case highlights the importance of considering CMI in older patients with unexplained weight loss and cardiovascular risk factors. Early recognition and timely intervention are crucial to prevent irreversible complications and ensure favourable outcomes.<\/jats:p>","DOI":"10.1136\/bcr-2025-267899","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:47:19Z","timestamp":1782229639000},"page":"e267899","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic mesenteric ischaemia: an overlooked cause of unintentional weight loss"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-7164","authenticated-orcid":false,"given":"Jo\u00e3o Ricardo Cordeiro Rei De Campos","family":"Faia","sequence":"first","affiliation":[{"name":"Internal Medicine, Unidade Local de Sa\u00fade da Regi\u00e3o de Aveiro, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-0043","authenticated-orcid":false,"given":"Ana","family":"Paiva Santos","sequence":"additional","affiliation":[{"name":"Internal Medicine, Unidade Local de Sa\u00fade da Regi\u00e3o de Aveiro, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-7232","authenticated-orcid":false,"given":"Sofia","family":"Martins","sequence":"additional","affiliation":[{"name":"Internal Medicine, Unidade Local de Sa\u00fade da Regi\u00e3o de Aveiro, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-4336","authenticated-orcid":false,"given":"Guilherme","family":"Violante Cunha","sequence":"additional","affiliation":[{"name":"Internal Medicine, Unidade Local de Sa\u00fade da Regi\u00e3o de Aveiro, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"2026062306350568000_19.6.e267899.1","article-title":"A Case of Chronic Mesenteric Ischemia Due to Celiac and Mesenteric Artery Thrombosis","volume":"15","author":"Malik","year":"2023","journal-title":"Cureus"},{"key":"2026062306350568000_19.6.e267899.2","first-page":"34","article-title":"Unintentional Weight Loss in Older Adults","volume":"104","author":"Gaddey","year":"2021","journal-title":"Am Fam Physician"},{"key":"2026062306350568000_19.6.e267899.3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/2050640620916681","article-title":"European guidelines on chronic mesenteric ischaemia \u2013 joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy and Nutrition, European Society of Gastrointestinal and Abdominal Radiology, Netherlands Association of Hepatogastroenterologists, Hellenic Society of Gastroenterology, Cardiovascular and Interventional Radiological Society of Europe, and Dutch Mesenteric Ischemia Study group clinical guidelines on the diagnosis and treatment of patients with chronic mesenteric ischaemia","volume":"8","author":"Terlouw","year":"2020","journal-title":"UEG Journal"},{"key":"2026062306350568000_19.6.e267899.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2020.08.019"},{"key":"2026062306350568000_19.6.e267899.5","doi-asserted-by":"crossref","unstructured":"Xhepa G , Vanzulli A , Sciacqua LV , et al . n.d. 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