{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:29:37Z","timestamp":1767806977973,"version":"3.49.0"},"reference-count":22,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,12,17]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Circumscribed astrocytic glioma, defined by the 2021 WHO Central Nervous System tumour classification, exhibits expansive growth patterns. Despite increasing molecular and histological data, their applicability to adolescents and young adults remains uncertain. Also, the coexistence of T-cell lymphoblastic lymphoma (T-LBL) and circumscribed astrocytic glioma is rare, and no established treatment protocols currently exist.<\/jats:p>\n                  <jats:p>A male in his late teens presented with T-LBL and concurrent intracranial masses in the left paracentral lobule and occipital lobe. Despite achieving a complete response for T-LBL with standard chemotherapy and transplantation, the intracranial lesion (paracentral lobule) progressed. Resection of the paracentral lesion revealed a circumscribed low-grade astrocytoma, not otherwise specified. At 1-year follow-up, without adjuvant therapy, no recurrence was observed and the residual occipital lesion decreased in size.<\/jats:p>\n                  <jats:p>Through interdepartmental collaboration, we achieved a favourable outcome, though the impact of T-LBL treatment on glioma remains unclear. Further studies are needed to establish optimal management for complex cases.<\/jats:p>","DOI":"10.1136\/bcr-2025-267939","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:45:43Z","timestamp":1767789943000},"page":"e267939","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Circumscribed low-grade astrocytoma with a synchronous occipital lesion of uncertain pathology in an adolescent with T-cell lymphoblastic lymphoma"],"prefix":"10.1136","volume":"19","author":[{"given":"Kazuho","family":"Karasudani","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7255-9776","authenticated-orcid":false,"given":"Narushi","family":"Sugii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Tokyo Medical University, Shinjuku, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Tsukuba, Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"2026010704453548000_19.1.e267939.1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"2026010704453548000_19.1.e267939.2","first-page":"884","article-title":"Circumscribed Astrocytic Gliomas","volume":"51","author":"Hayashi","year":"2023","journal-title":"No Shinkei Geka"},{"key":"2026010704453548000_19.1.e267939.3","unstructured":"Japan Society of Brain Tumor Pathology . Color Atlas of Brain Tumor Pathology. 5th edn. Japan: The Japan Society of Brain Tumor Pathology, 2024."},{"key":"2026010704453548000_19.1.e267939.4","first-page":"S33","article-title":"Circumscribed astrocytic gliomas: Contribution of molecular analyses to histopathology diagnosis in the WHO CNS5 classification","volume":"65","author":"K\u00f6y","year":"2022","journal-title":"Indian J Pathol Microbiol"},{"key":"2026010704453548000_19.1.e267939.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.0242"},{"key":"2026010704453548000_19.1.e267939.6","article-title":"Adolescent and young adult glioma: systematic review of demographic, disease, and treatment influences on survival","volume":"4","author":"Malhotra","year":"2022","journal-title":"Neurooncol Adv"},{"key":"2026010704453548000_19.1.e267939.7","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1254645","article-title":"Bridging the age gap: a review of molecularly informed treatments for glioma in adolescents and young adults","volume":"13","author":"Weiser","year":"2023","journal-title":"Front Oncol"},{"key":"2026010704453548000_19.1.e267939.8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.21147\/j.issn.1000-9604.2022.02.03","article-title":"Genomic landscape of T-cell lymphoblastic lymphoma","volume":"34","author":"Li","year":"2022","journal-title":"Chin J Cancer Res"},{"key":"2026010704453548000_19.1.e267939.9","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01392-1"},{"key":"2026010704453548000_19.1.e267939.10","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1553142","article-title":"Case Report: Hypothalamic demyelinating lesion preceding lymphoma arising outside the central nervous system","volume":"15","author":"Sugii","year":"2025","journal-title":"Front Oncol"},{"key":"2026010704453548000_19.1.e267939.11","article-title":"Multicentric Spinal Pilocytic Astrocytoma Presenting with Syringomyelia","volume":"13","author":"Alanazi","year":"2021","journal-title":"Cureus"},{"key":"2026010704453548000_19.1.e267939.12","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3171\/jns.2004.100.4.0700","article-title":"Oligodendroglioma and juvenile pilocytic astrocytoma presenting as synchronous primary brain tumors","volume":"100","author":"Kan","year":"2004","journal-title":"J Neurosurg"},{"key":"2026010704453548000_19.1.e267939.13","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3171\/2012.9.JNS112353","article-title":"Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations","volume":"118","author":"Kanoke","year":"2013","journal-title":"J Neurosurg"},{"key":"2026010704453548000_19.1.e267939.14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2176\/nmc.45.411","article-title":"Multi focal Pilocytic Astrocytomas With Ependymal Differentiation in the Bilateral Medial Temporal Lobes-Case Report-","volume":"45","author":"Maruyama","year":"2005","journal-title":"Neurol Med Chir(Tokyo)"},{"key":"2026010704453548000_19.1.e267939.15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3171\/jns.1994.81.1.0024","article-title":"Treatment options and prognosis for multicentric juvenile pilocytic astrocytoma","volume":"81","author":"Mamelak","year":"1994","journal-title":"J Neurosurg"},{"key":"2026010704453548000_19.1.e267939.16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10014-010-0015-z","article-title":"Spontaneous regression of multicentric pilocytic astrocytoma with CSF dissemination in an adult","volume":"28","author":"Sakai","year":"2011","journal-title":"Brain Tumor Pathol"},{"key":"2026010704453548000_19.1.e267939.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2012.09.046"},{"key":"2026010704453548000_19.1.e267939.18","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.2.0376"},{"key":"2026010704453548000_19.1.e267939.19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.5414\/NP300411","article-title":"Astroblastoma - a case report of a rare neuroepithelial tumor with complete remission after chemotherapy","volume":"30","author":"Bergk\u00e5sa","year":"2011","journal-title":"Clin Neuropathol"},{"key":"2026010704453548000_19.1.e267939.20","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1182\/blood.2020005381","article-title":"Integrative genomic analysis of pediatric T-cell lymphoblastic lymphoma reveals candidates of clinical significance","volume":"137","author":"Khanam","year":"2021","journal-title":"Blood"},{"key":"2026010704453548000_19.1.e267939.21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s003810050443","article-title":"Multicentric juvenile pilocytic astrocytoma occurring primarily in the trigone of the lateral ventricle","volume":"15","author":"Sim","year":"1999","journal-title":"Childs Nerv Syst"},{"key":"2026010704453548000_19.1.e267939.22","doi-asserted-by":"crossref","first-page":"811151","DOI":"10.3389\/fonc.2022.811151","article-title":"Prognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation Sequencing","volume":"12","author":"Yin","year":"2022","journal-title":"Front Oncol"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-267939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:45:45Z","timestamp":1767789945000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-267939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,7]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/bcr-2025-267939"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-267939","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}