{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:14:39Z","timestamp":1756167279477,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,8,7]]},"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Epstein-Barr virus (EBV) is a ubiquitous pathogen, with an estimated over 90% of adults worldwide having been exposed to it. EBV primarily affects immunocompromised individuals, with the most common presentation as infectious mononucleosis characterised by fever, sore throat, lymphadenopathy and fatigue. While these manifestations are well recognised, EBV-associated pneumonia and meningitis are rare complications, often posing diagnostic challenges due to their atypical presentation. Here, we present a male patient in his sixth decade with a 30-day history of prevailing symptoms, presenting with pneumosepsis as evident on chest imaging and low Glasgow Coma Scale. Initial management along the lines of severe community-acquired pneumonia did not improve the disease, which led to further workup and was finally proved to be concurrent EBV pneumonia with EBV meningitis by PCR positive from endotracheal aspirate and cerebrospinal fluid sample. He was treated with intravenous acyclovir, but succumbed to his illness on day 6 of admission.<\/jats:p>","DOI":"10.1136\/bcr-2025-267949","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T19:05:36Z","timestamp":1756148736000},"page":"e267949","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Concurrent pneumonia and meningoencephalitis in an immunocompetent host: an atypical manifestation of Epstein-Barr virus"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-869X","authenticated-orcid":false,"given":"Mohammed","family":"Ayyub","sequence":"first","affiliation":[{"name":"Pulmonology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathri Sindhu","family":"Rajeev","sequence":"additional","affiliation":[{"name":"Pulmonology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod","family":"Govindasaami","sequence":"additional","affiliation":[{"name":"Pulmonology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hari","family":"Prasad","sequence":"additional","affiliation":[{"name":"Pulmonology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"2025082512052984000_18.8.e267949.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2001.iep190.x"},{"key":"2025082512052984000_18.8.e267949.2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmmb.2024.100643","article-title":"Seroprevalence and characterization of Epstein-Barr virus exposure among paediatric population","volume":"50","author":"Garg","year":"2024","journal-title":"Indian J Med Microbiol"},{"key":"2025082512052984000_18.8.e267949.3","article-title":"Never too old: A case of fatal epstein barr virus pneumonia in an immunocompetent adult","volume":"47","author":"Tanba","year":"2024","journal-title":"Respir Med Case Rep"},{"key":"2025082512052984000_18.8.e267949.4","article-title":"Epstein-Barr Virus Encephalitis in an Immunocompetent Child: A Case Report and Management of Epstein-Barr Virus Encephalitis","volume":"2016","author":"Akkoc","year":"2016","journal-title":"Case Rep Infect Dis"},{"key":"2025082512052984000_18.8.e267949.5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1542\/peds.59.1.16","article-title":"Primary Epstein-Barr virus infections in children","volume":"59","author":"Sumaya","year":"1977","journal-title":"Pediatrics"},{"key":"2025082512052984000_18.8.e267949.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)95379-1"},{"key":"2025082512052984000_18.8.e267949.7","doi-asserted-by":"crossref","unstructured":"Howley PM , DeMasi J . Chapter 6 - infectious agents and cancer. In: Mendelsohn J , Howley PM , Israel MA , et al , eds. The molecular basis of cancer. 3rd edn. Philadelphia: W.B. Saunders, 2008: 67\u201389.","DOI":"10.1016\/B978-141603703-3.10006-8"},{"key":"2025082512052984000_18.8.e267949.8","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.2147\/IDR.S434929","article-title":"A Case of Adult Epstein-Barr Virus-Associated Pneumonia with Multiple Cavitary Pulmonary Lesions Confirmed by Lung Biopsy mNGS: A Case Report","volume":"16","author":"Zhuang","year":"2023","journal-title":"Infect Drug Resist"},{"key":"2025082512052984000_18.8.e267949.9","unstructured":"Centers for Disease Control and Prevention . Epstein-barr virus and infectious mononucleosis. Atlanta: CDC; 2020. 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