{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T02:06:18Z","timestamp":1763949978305,"version":"3.45.0"},"reference-count":23,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,11,11]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>Rathke cleft cysts (RCCs) are non-tumorous cystic formations in the sellar and suprasellar regions. They arise from the failure of Rathke\u2019s pouch to regress during embryonic development. Most RCCs are discovered incidentally during autopsies and can remain stable or enlarge over time; spontaneous involution is rare. The most common symptoms of large RCCs include headaches, vision disturbances or hormonal imbalances. We present a case of a quadragenarian man with an incidentally detected RCC that showed spontaneous regression on follow-up MRI over 3 years. This article also discusses the radiological features, natural history and potential mechanisms behind the spontaneous resolution of RCCs.<\/jats:p>","DOI":"10.1136\/bcr-2025-267962","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T02:05:12Z","timestamp":1763949912000},"page":"e267962","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous involution of a Rathke\u2019s cleft cyst"],"prefix":"10.1136","volume":"18","author":[{"given":"Vandana","family":"M","sequence":"first","affiliation":[{"name":"Radiodiagnosis, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Samal","sequence":"additional","affiliation":[{"name":"Neurology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswajit","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Radiodiagnosis, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-2302","authenticated-orcid":false,"given":"Manoj Kumar","family":"Nayak","sequence":"additional","affiliation":[{"name":"Radiodiagnosis, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"2025112318050488000_18.11.e267962.1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11154-025-09949-6","article-title":"Rathke\u2019s cleft cyst: From history to molecular genetics","volume":"26","author":"Hacioglu","year":"2025","journal-title":"Rev Endocr Metab Disord"},{"key":"2025112318050488000_18.11.e267962.2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/B978-0-444-59602-4.00017-4","article-title":"Rathke\u2019s cleft cyst","volume":"124","author":"Larkin","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"2025112318050488000_18.11.e267962.3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3889\/oamjms.2018.115","article-title":"Rathke\u2019s Cleft Cyst or Pituitary Apoplexy: A Case Report and Literature Review","volume":"6","author":"Shatri","year":"2018","journal-title":"Open Access Maced J Med Sci"},{"key":"2025112318050488000_18.11.e267962.4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.wneu.2017.04.128","article-title":"Metabolic In Vivo Visualization of Pituitary Adenomas: a Systematic Review of Imaging Modalities","volume":"104","author":"Yao","year":"2017","journal-title":"World Neurosurg"},{"key":"2025112318050488000_18.11.e267962.5","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199410000-00008"},{"key":"2025112318050488000_18.11.e267962.6","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2004.100.1.0033"},{"key":"2025112318050488000_18.11.e267962.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02446.x"},{"key":"2025112318050488000_18.11.e267962.8","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1210\/clinem\/dgac033","article-title":"Approach to the Patient: Differential Diagnosis of Cystic Sellar Lesions","volume":"107","author":"Gadelha","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"2025112318050488000_18.11.e267962.9","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s11604-023-01407-0","article-title":"Imaging of pituitary tumors: an update with the 5th WHO Classifications\u2014part 2. 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