{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:17:12Z","timestamp":1788675432847,"version":"build-2803163510"},"reference-count":24,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,6,27]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Here, we report a novel case of amikacin-resistant atypical mycobacterial keratitis in a man in his third decade. He presented with gradual diminution of vision associated with pain, redness, watering in his left eye of 1\u00bd months' duration, with a characteristic cracked windshield appearance of corneal ulcer. Smear as well as culture showed the presence of atypical mycobacterial species. Based on clinical and microbiological results, 1% amikacin sulfate eye drops was started. However, the subsequent sensitivity report revealed resistance to amikacin. Following this, other broad-spectrum antibiotics were tested in a microbiology laboratory to find an alternative drug and the organism was found sensitive to gentamicin. The patient responded well to fortified gentamicin eye drops.<\/jats:p>\n                  <jats:p>Gentamicin is not routinely used for the treatment of atypical mycobacterial keratitis. However, in cases resistant to amikacin, other broad-spectrum antibiotics should be tested to determine an alternative and suitable antimicrobial drug.<\/jats:p>","DOI":"10.1136\/bcr-2025-268190","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:20:14Z","timestamp":1784730014000},"page":"e268190","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Amikacin-resistant atypical mycobacterial keratitis"],"prefix":"10.1136","volume":"19","author":[{"given":"Nisha Vilas","family":"Rahul","sequence":"first","affiliation":[{"name":"Cornea and Anterior Segment Services, L V Prasad Eye Institute, Bhubaneswar Campus, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himansu Sekhar","family":"Behera","sequence":"additional","affiliation":[{"name":"Ocular Microbiology Services, L V Prasad Eye Institute, Bhubaneswar Campus, Bhubaneswar, Odisha, 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