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At 2 years, she remains disease-free. This case highlights the diagnostic challenge of accessory axillary breast cancer (AABC), a rare entity often missed on routine imaging. Early recognition and application of standard breast cancer treatment protocols can result in excellent outcomes. Clinicians should maintain a high index of suspicion for AABC in axillary masses, especially in patients with no primary breast findings on imaging to ensure timely diagnosis and appropriate management.<\/jats:p>","DOI":"10.1136\/bcr-2025-268191","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:30:17Z","timestamp":1777041017000},"page":"e268191","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic challenges and management of primary accessory axillary breast cancer"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-1496","authenticated-orcid":false,"given":"Jessica","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Surgery, University of Miami Miller School of Medicine, Holy Cross Hospital, Fort Lauderdale, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedant","family":"Singh","sequence":"additional","affiliation":[{"name":"Surgery, University of Miami Miller School of Medicine, Holy Cross Hospital, Fort Lauderdale, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Burgers","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Holy Cross Hospital, Fort Lauderdale, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"2026042407301030000_19.4.e268191.1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/1754-9485.12579","article-title":"Review of axillary lesions, emphasising some distinctive imaging and pathology findings","volume":"61","author":"Gupta","year":"2017","journal-title":"J Med Imaging Radiat Oncol"},{"key":"2026042407301030000_19.4.e268191.2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3233\/BD-201027","article-title":"Primary ectopic breast carcinoma in the axilla: A rare presentation and review of the literature","volume":"40","author":"Salemis","year":"2021","journal-title":"Breast Dis"},{"key":"2026042407301030000_19.4.e268191.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4274\/ejbh.galenos.2021.2021-7-3","article-title":"Axillary Reverse Lymphatic Mapping in the Treatment of Axillary Accessory Breast Cancer: A Case Report and Review of Management","volume":"18","author":"Friedman-Eldar","year":"2022","journal-title":"Eur J Breast Health"},{"key":"2026042407301030000_19.4.e268191.4","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-241361","article-title":"Case of second primary breast cancer in ectopic breast tissue and review of the literature","volume":"14","author":"Addae","year":"2021","journal-title":"BMJ Case Rep"},{"key":"2026042407301030000_19.4.e268191.5","first-page":"31","article-title":"Radiation Therapy in Cancer of Accessory Breast Tissue: Questions for Treatment Guidelines, Case Series, and Literature Review","volume":"1","author":"Polce","year":"2023","journal-title":"ARO"},{"key":"2026042407301030000_19.4.e268191.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2009.09.005"},{"key":"2026042407301030000_19.4.e268191.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.10.034"},{"key":"2026042407301030000_19.4.e268191.8","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199509000-00002"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-268191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T14:30:18Z","timestamp":1777041018000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-268191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,4,24]]},"published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1136\/bcr-2025-268191"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-268191","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}