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Cerebrospinal fluid and blood samples tested positive for cryptococcal antigens. A final diagnosis of disseminated cryptococcosis was made, and the patient was started on liposomal amphotericin B and oral fluconazole. The patient showed clinical and radiological improvement. This case highlights the fact that not all pulmonary masses are necessarily malignant. Hence, it is essential to consider non-malignant causes, particularly cryptococcosis, in immunocompromised individuals.<\/jats:p>","DOI":"10.1136\/bcr-2025-268243","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T08:00:24Z","timestamp":1760428824000},"page":"e268243","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Disseminated cryptococcosis presenting as lung mass"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6565-2263","authenticated-orcid":false,"given":"Manish","family":"Shankar","sequence":"first","affiliation":[{"name":"Pulmonary Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-8564","authenticated-orcid":false,"given":"Satyadeo","family":"Choubey","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3744-3456","authenticated-orcid":false,"given":"Arshad","family":"Ejazi","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3711-2716","authenticated-orcid":false,"given":"R","family":"Thanisk","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"2025101401001577000_18.10.e268243.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.006"},{"key":"2025101401001577000_18.10.e268243.2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295720"},{"key":"2025101401001577000_18.10.e268243.3","first-page":"438","article-title":"Clinical and radiologic manifestations of pulmonary cryptococcosis in immunocompetent patients and their outcomes after treatment","volume":"19","author":"Suwatanapongched","year":"2013","journal-title":"Diagn Interv Radiol"},{"key":"2025101401001577000_18.10.e268243.4","unstructured":"WHO fungal priority pathogens list to guide research, development and public health action 1st ed. 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