{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:08:03Z","timestamp":1790240883224,"version":"4.1.0"},"reference-count":10,"publisher":"BMJ","issue":"9","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2026,9,14]]},"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Solitary circumscribed neuroma (SCN), also known as a palisaded encapsulated neuroma, is characterised by a firm dome shape. These lesions are most commonly located in the head and neck regions near mucocutaneous junctions in adult patients. To date, SCN has rarely been reported on the eyelid. Clinically, these tumours present as slowly growing papules, often exhibiting a polypoid appearance. Histologically, they consist of Schwann cell and axon overgrowth and may be surrounded by a perineural capsule. Differential diagnosis should include other neural tumours associated with systemic conditions, such as neurofibromatosis and multiple endocrine neoplasia type 2b. In the presented case, the lesion was painless and histopathologic examination revealed a partially circumscribed, non-encapsulated dermal spindle cell proliferation, positive for S100. The tumour was successfully excised and there has been no evidence of recurrence to date. This represents a rare occurrence of SCN on the eyelid.<\/jats:p>","DOI":"10.1136\/bcr-2025-268497","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:40:29Z","timestamp":1790239229000},"page":"e268497","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Solitary circumscribed neuroma of the mucocutaneous eyelid margin"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6540-230X","authenticated-orcid":false,"given":"Carson E","family":"Clabeaux","sequence":"first","affiliation":[{"name":"Ophthalmology, Madigan Army Medical Center, Tacoma, Washington, USA"},{"name":"Uniformed Services University of the Health Sciences F Edward H\u00e9bert School of Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C","family":"Casey","sequence":"additional","affiliation":[{"name":"Walter Reed Army Medical Center, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Heller","sequence":"additional","affiliation":[{"name":"West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia, USA"},{"name":"Brooke Army Medical Center, Joint Base San Antonio Fort Sam Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladamir S","family":"Yakopson","sequence":"additional","affiliation":[{"name":"Ophthalmology, Madigan Army Medical Center, Tacoma, Washington, USA"},{"name":"Uniformed Services University of the Health Sciences F Edward H\u00e9bert School of Medicine, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"2026092401400860000_19.9.e268497.1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12105-010-0162-x","article-title":"Palisaded encapsulated (\u201csolitary circumscribed\u201d) neuroma of the oral cavity: a review of 55 cases","volume":"4","author":"Koutlas","year":"2010","journal-title":"Head Neck Pathol"},{"key":"2026092401400860000_19.9.e268497.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80068-5"},{"key":"2026092401400860000_19.9.e268497.3","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1111\/ijd.12828","article-title":"Solitary circumscribed neuroma: a clinical and dermoscopic mimicker of basal cell carcinoma","volume":"54","author":"Fern\u00e1ndez-Crehuet","year":"2015","journal-title":"Int J Dermatol"},{"key":"2026092401400860000_19.9.e268497.4","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.8.949"},{"key":"2026092401400860000_19.9.e268497.5","first-page":"ZD32","article-title":"\u201cRare or Underdiagnosed?\u201d - Solitary Circumscribed Neuroma of the Lip","volume":"9","author":"Panthula","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"2026092401400860000_19.9.e268497.6","unstructured":"Scheithauer BW , Woodruff JM , Erlandson RA . 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Philadelphia, PA: Elsevier, 2010."}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-268497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:40:31Z","timestamp":1790239231000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-268497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":10,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,24]]},"published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1136\/bcr-2025-268497"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-268497","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}