{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:00:51Z","timestamp":1777111251103,"version":"3.51.4"},"reference-count":13,"publisher":"BMJ","issue":"11","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Case Rep"],"accepted":{"date-parts":[[2025,11,7]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>We report the first known case of eosinophilic pneumonitis induced by bedaquiline, a drug increasingly used off-label for non-tuberculous mycobacterial infections. While bedaquiline is generally well tolerated, its potential to cause pulmonary hypersensitivity reactions has not been previously reported. This case highlights the need for heightened clinical awareness of novel adverse effects as bedaquiline use expands beyond its original indication for multidrug-resistant tuberculosis. Clinicians should consider eosinophilic pneumonitis in patients developing new respiratory symptoms and peripheral eosinophilia while on bedaquiline, ensuring timely diagnosis and management to prevent serious complications.<\/jats:p>","DOI":"10.1136\/bcr-2025-268609","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:45:22Z","timestamp":1764215122000},"page":"e268609","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Bedaquiline-induced eosinophilic pneumonitis in treatment-refractory mycobacterium avium complex (MAC) lung disease"],"prefix":"10.1136","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-567X","authenticated-orcid":false,"given":"Irfan","family":"Shafiq","sequence":"first","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Isse","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaid","family":"Zoumot","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuayb","family":"Elkhalifa","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE"},{"name":"The University of Manchester Faculty of Biology Medicine and Health, Manchester, England, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateen","family":"Uzbeck","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammarah A","family":"Tarar","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Saeed","family":"Wahla","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Abu Dhabi, Abu Dhabi, Abu Dhabi, UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"2025112619451370000_18.11.e268609.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.10.002"},{"key":"2025112619451370000_18.11.e268609.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2014.11.002"},{"key":"2025112619451370000_18.11.e268609.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201205-0913OC"},{"key":"2025112619451370000_18.11.e268609.4","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00535-2020","article-title":"Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline","volume":"56","author":"Daley","year":"2020","journal-title":"Eur Respir J"},{"key":"2025112619451370000_18.11.e268609.5","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"key":"2025112619451370000_18.11.e268609.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.01.024"},{"key":"2025112619451370000_18.11.e268609.7","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01799-2016","article-title":"Long-term outcome and safety of prolonged bedaquiline treatment for multidrug-resistant tuberculosis","volume":"49","author":"Guglielmetti","year":"2017","journal-title":"Eur Respir J"},{"key":"2025112619451370000_18.11.e268609.8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/jac\/dkad372","article-title":"Bedaquiline for treatment of non-tuberculous mycobacteria (NTM): a systematic review and meta-analysis","volume":"79","author":"Omar","year":"2024","journal-title":"J Antimicrob Chemother"},{"key":"2025112619451370000_18.11.e268609.9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-2764"},{"key":"2025112619451370000_18.11.e268609.10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tube.2014.04.001","article-title":"Bedaquiline for the treatment of resistant tuberculosis: promises and pitfalls","volume":"94","author":"Kakkar","year":"2014","journal-title":"Tuberculosis (Edinb)"},{"key":"2025112619451370000_18.11.e268609.11","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofad414","article-title":"Pharmacovigilance Study on Eosinophilic Pneumonia Induced by Anti-MRSA Agents: Analysis Based on the FDA Adverse Event Reporting System","volume":"10","author":"Okada","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"2025112619451370000_18.11.e268609.12","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000009688","article-title":"Drug-induced eosinophilic pneumonia: A review of 196 case reports","volume":"97","author":"Bartal","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"2025112619451370000_18.11.e268609.13","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.43.231"}],"container-title":["BMJ Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bcr-2025-268609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:45:23Z","timestamp":1764215123000},"score":1,"resource":{"primary":{"URL":"https:\/\/casereports.bmj.com\/lookup\/doi\/10.1136\/bcr-2025-268609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":13,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11,26]]},"published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1136\/bcr-2025-268609"],"URL":"https:\/\/doi.org\/10.1136\/bcr-2025-268609","relation":{},"ISSN":["1757-790X"],"issn-type":[{"value":"1757-790X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}