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Cerebrospinal fluid analysis demonstrated significantly elevated 14-3-3 and T-tau proteins, making sporadic Creutzfeldt-Jakob disease probable. This case illustrates how early prion disease can mimic stroke radiographically and clinically, underscoring the importance of reconsidering the diagnosis when neurological deficits progress rapidly and atypically.<\/jats:p>","DOI":"10.1136\/bcr-2025-268638","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T15:30:34Z","timestamp":1768231834000},"page":"e268638","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rapidly progressive sensorineural hearing loss due to sporadic Creutzfeldt-Jakob disease"],"prefix":"10.1136","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-3044","authenticated-orcid":false,"given":"Wilson","family":"Guo","sequence":"first","affiliation":[{"name":"Warren Alpert Medical School, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Khurana","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seo Youn","family":"Chang","sequence":"additional","affiliation":[{"name":"Brown University Health Department of Neurology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fransisca","family":"Indraswari","sequence":"additional","affiliation":[{"name":"Brown University Health Department of Neurology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Cahill","sequence":"additional","affiliation":[{"name":"Brown University Health Department of Neurology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Brown University Health Department of Neurology, Brown University Warren Alpert Medical School, Providence, Rhode Island, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"2026011207301670000_19.1.e268638.1","unstructured":"Clinical overview of creutzfeldt-jakob disease (CJD). 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